{"id":2328,"date":"2021-01-27T00:11:00","date_gmt":"2021-01-27T00:11:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=2328"},"modified":"2025-10-01T11:45:05","modified_gmt":"2025-10-01T19:45:05","slug":"usmle-step-1-question-human-leukocyte-antigen-complex","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex","title":{"rendered":"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\/#The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\" >The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\/#E_HLA-DR3\" >E. HLA-DR3<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\/#Incorrect_answer_explanations\" >Incorrect answer explanations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\/#Correct_answer_explanation\" >Correct answer explanation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\/#Major_takeaways\" >Major takeaways<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><strong><em>Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a young girl who is worried because of recent urinary issues and weight loss. These symptoms are upsetting her because she is trying to keep a certain weight for boxing lessons. Can you help her figure out what&#8217;s happening by determining which gene is most likely present in her human leukocyte antigen complex?<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 12-year-old girl is brought to the clinic due to complaints of frequent, high-volume urination. For the past two months, the patient has been experiencing more frequent episodes of urination throughout the day, and the father says that the patient has been waking up at least three times a night to urinate. She has developed an unquenchable thirst and keeps a 2-liter water bottle next to her at all times. The patient is upset that she is losing weight despite eating more than normal to reach a certain size for boxing lessons. Her mother has a history of vitiligo. The patient\u2019s temperature is 37.0\u00b0C (98.6\u00b0F), pulse is 100\/min, respirations are 20\/min, and blood pressure is 90\/65 mmHg. Physical examination shows a tired-looking young female with dry mucous membranes and secondary sex characteristics consistent with Tanner stage II. Which of the following genes is most likely present in this patient\u2019s human leukocyte antigen complex?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. HLA-A3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. HLA-B27<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. HLA-DPB1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. HLA-DQB1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. HLA-DR3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;Scroll down to find the answer!<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Osmosis.org at Vanderbilt University in Nashville, TN\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/xKcGSaRy9pI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><u><em><strong>\u2192 Reinforce your understanding with more self-assessment items on Osmosis.<\/strong><\/em><\/u><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"E_HLA-DR3\"><\/span>E. HLA-DR3<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This patient likely has&nbsp;<strong>Type 1 Diabetes Mellitus (T1DM)<\/strong>. Before we go into the full answer explanation, let&#8217;s review the incorrect answers.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_answer_explanations\"><\/span>Incorrect answer explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The incorrect answers to today&#8217;s USMLE\u00ae Step 1 Question are&#8230;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A. HLA-A3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;The HLA-A3 gene within the human leukocyte antigen complex is associated with increased susceptibility to&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Multiple_sclerosis\" target=\"_blank\" rel=\"noreferrer noopener\">multiple sclerosis<\/a>, possibly by presenting myelin PLP1 self-peptide to autoreactive CD8-positive T cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B. HLA-B27<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>The HLA-B27 gene within the human leukocyte antigen complex is associated with increased susceptibility to&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Ankylosing_spondylitis\" target=\"_blank\" rel=\"noreferrer noopener\">ankylosing spondylitis<\/a>, Beh\u00e7et disease, juvenile idiopathic arthritis,<a href=\"https:\/\/www.osmosis.org\/learn\/Psoriatic_arthritis?from=\/medicine-preclinical\/musculoskeletal\/pathology\/inflammatory-conditions\/inflammatory-arthritis\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;psoriatic arthritis<\/a>,&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Rheumatoid_arthritis\" target=\"_blank\" rel=\"noreferrer noopener\">rheumatoid arthritis<\/a>, shingles, and Steven-Johnson syndrome\/toxic epidermal necrolysis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C. HLA-DPB1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>The HLA-DPB1 gene within the human leukocyte antigen complex is associated with increased susceptibility to granulomatosis with polyangiitis, juvenile idiopathic arthritis, and rheumatoid arthritis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D. HLA-DQB1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>The HLA-DQB1 gene within the human leukocyte antigen complex is associated with increased susceptibility to&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/High_Yield:_Sleep_disorders\" target=\"_blank\" rel=\"noreferrer noopener\">narcolepsy<\/a>&nbsp;with cataplexy. Most people with narcolepsy with cataplexy have a variant of the HLA-DQB1 gene.<br><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Correct_answer_explanation\"><\/span>Correct answer explanation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This patient is experiencing the classic symptoms associated with uncontrolled hyperglycemia, including polyuria, polydipsia, and weight loss with polyphagia. Along with her mother\u2019s history of vitiligo, which suggests a possible inherited autoimmune-associated gene, this patient most likely has&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/High_Yield:_Diabetes_mellitus\" target=\"_blank\" rel=\"noreferrer noopener\">type 1 diabetes mellitus (T1DM).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In T1DM, the immune system targets and destroys the beta-cells of the pancreas. A common target is an enzyme inside beta cells called glutamic acid decarboxylase (GAD), which helps make gamma-aminobutyric acid or GABA. GABA increases insulin release and also has a protective effect on the beta-cells. Without the protective effect of GABA, the number of beta cells progressively decreases, leading to the loss of endogenous insulin and the elevation of blood sugar levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The gene complex involved in the regulation of the immune response, which is often associated with various autoimmune conditions, is called the human leukocyte antigen (HLA) system. These genes code for the major histocompatibility complex, or MHC, which is a protein that helps the immune system recognize foreign molecules and maintain self-tolerance. People with T1DM often have specific HLA haplotype genes in common: HLA-DR3 and HLA-DR4.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" height=\"1024\" width=\"1024\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/HLA-DR3-Diabetes-1.png?w=1024\" alt=\"\" class=\"wp-image-4623\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/HLA-DR3-Diabetes-1.png 1080w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/HLA-DR3-Diabetes-1.png?resize=150,150 150w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/HLA-DR3-Diabetes-1.png?resize=300,300 300w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/HLA-DR3-Diabetes-1.png?resize=768,769 768w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/HLA-DR3-Diabetes-1.png?resize=1024,1024 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" height=\"1024\" width=\"1024\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/Step_1_QOTD_-_Diabetes_Mellitus_Answer1b.png?w=1024\" alt=\"\" class=\"wp-image-4627\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/Step_1_QOTD_-_Diabetes_Mellitus_Answer1b.png 1081w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/Step_1_QOTD_-_Diabetes_Mellitus_Answer1b.png?resize=150,150 150w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/Step_1_QOTD_-_Diabetes_Mellitus_Answer1b.png?resize=300,300 300w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/Step_1_QOTD_-_Diabetes_Mellitus_Answer1b.png?resize=768,768 768w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2021\/01\/Step_1_QOTD_-_Diabetes_Mellitus_Answer1b.png?resize=1024,1024 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">In T1DM, the destruction of beta cells usually starts early in life, and individuals present with symptoms of diabetes before the age of 30. Their tissues are sensitive to insulin, but since there are fewer beta-cells, insulin levels are very low.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In contrast, type 2 diabetes mellitus (T2DM) is defined by insulin resistance. Risk factors for T2DM include obesity, environmental factors, and a multitude of heritable genetic factors. Insulin levels are increased at the start, but as the islet cells tire out and die, the level drops. T2DM usually manifests after the age of 40 and presents similarly to type 1 diabetes with polyuria, polydipsia, polyphagia, and unintentional weight loss.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Major_takeaways\"><\/span>Major takeaways<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Type 1 diabetes mellitus (T1DM) is an autoimmune condition that is associated with HLA-DR3 and HLA-DR4 genes. Destruction of pancreatic beta cells causes insulin levels to drop. Risk factors include a family history of autoimmune disorders.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Powers, A. C., Niswender, K. D., &amp; Evans-Molina, C. (2018). Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology. In J. L. Jameson, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, &amp; J. Loscalzo (Eds.), Harrison\u2019s Principles of Internal Medicine (20th ed.). McGraw-Hill Education.<a href=\"https:\/\/doi.org\/accessmedicine.mhmedical.com\/content.aspx?aid=1156520865\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;<\/a><a href=\"https:\/\/doi.org\/accessmedicine.mhmedical.com\/content.aspx?aid=1156520865\" target=\"_blank\" rel=\"noreferrer noopener\">accessmedicine.mhmedical.com\/content.aspx?aid=1156520865<\/a><\/li>\n\n\n\n<li>Histocompatibility complex. Genetics Home Reference. Retrieved March 28, 2020, from<a href=\"https:\/\/ghr.nlm.nih.gov\/primer\/genefamily\/hla\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;https:\/\/ghr.nlm.nih.gov\/primer\/genefamily\/hla<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Want more USMLE\u00ae Step 1 practice questions? Try Osmosis today! Access your&nbsp;<a href=\"https:\/\/www.osmosis.org\/login?type=create\" target=\"_blank\" rel=\"noreferrer noopener\">free trial<\/a>&nbsp;and find out why millions of current and future clinicians and caregivers love learning with us.<\/em><\/strong><br><strong><em><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/em><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.osmosis.org\/plans\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_169cbe.png\" alt=\"The most powerful platform for learning medicine\" class=\"wp-image-2330\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_169cbe.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_169cbe.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The United States Medical Licensing Examination (USMLE\u00ae) is a joint program of the Federation of State Medical Boards (FSMB\u00ae) and National Board of Medical Examiners (NBME\u00ae). Osmosis is not affiliated with NBME nor FSMB.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a young girl who is worried because of recent urinary issues and weight loss. These symptoms are upsetting her because she is trying to keep a certain weight for boxing lessons. Can you help her [&hellip;]<\/p>\n","protected":false},"author":202,"featured_media":2329,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[27,20,44],"tags":[],"class_list":["post-2328","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-exam-prep","category-step-1"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a young girl who is worried because of recent urinary issues and weight loss. These symptoms are upsetting her because she is trying to keep a certain weight for boxing lessons. Can you help her [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\" \/>\n<meta property=\"og:site_name\" content=\"Osmosis Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-27T00:11:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-01T19:45:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1081\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Marina Horiates Kerekes, MD &amp; Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\"},\"author\":{\"name\":\"Marina Horiates Kerekes, MD &amp; Team\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc\"},\"headline\":\"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex\",\"datePublished\":\"2021-01-27T00:11:00+00:00\",\"dateModified\":\"2025-10-01T19:45:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\"},\"wordCount\":936,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp\",\"articleSection\":[\"Allopathic Medicine (MD)\",\"Exam Prep\",\"USMLE\u00ae Step 1\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\",\"url\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\",\"name\":\"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex - Osmosis Blog\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp\",\"datePublished\":\"2021-01-27T00:11:00+00:00\",\"dateModified\":\"2025-10-01T19:45:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage\",\"url\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp\",\"contentUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp\",\"width\":1081,\"height\":1080,\"caption\":\"USMLE\u00ae Step 1 Question: Human Leukocyte Antigen Complex\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.osmosis.org\/blog\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#website\",\"url\":\"https:\/\/www.osmosis.org\/blog\/\",\"name\":\"Osmosis Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.osmosis.org\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#organization\",\"name\":\"Osmosis Blog\",\"url\":\"https:\/\/www.osmosis.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png\",\"contentUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png\",\"width\":1276,\"height\":596,\"caption\":\"Osmosis Blog\"},\"image\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc\",\"name\":\"Marina Horiates Kerekes, MD &amp; Team\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g\",\"caption\":\"Marina Horiates Kerekes, MD &amp; Team\"},\"description\":\"Authors: Marina Horiates Kerekes, MD &amp; Osmosis Question Writing Team\",\"url\":\"https:\/\/www.osmosis.org\/blog\/author\/marinahoriateskerekesandteam\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex - Osmosis Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex","og_locale":"en_US","og_type":"article","og_title":"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex - Osmosis Blog","og_description":"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a young girl who is worried because of recent urinary issues and weight loss. These symptoms are upsetting her because she is trying to keep a certain weight for boxing lessons. Can you help her [&hellip;]","og_url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex","og_site_name":"Osmosis Blog","article_published_time":"2021-01-27T00:11:00+00:00","article_modified_time":"2025-10-01T19:45:05+00:00","og_image":[{"width":1081,"height":1080,"url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp","type":"image\/webp"}],"author":"Marina Horiates Kerekes, MD &amp; Team","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["Article","BlogPosting"],"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#article","isPartOf":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex"},"author":{"name":"Marina Horiates Kerekes, MD &amp; Team","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc"},"headline":"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex","datePublished":"2021-01-27T00:11:00+00:00","dateModified":"2025-10-01T19:45:05+00:00","mainEntityOfPage":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex"},"wordCount":936,"commentCount":0,"publisher":{"@id":"https:\/\/www.osmosis.org\/blog\/#organization"},"image":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage"},"thumbnailUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp","articleSection":["Allopathic Medicine (MD)","Exam Prep","USMLE\u00ae Step 1"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex","url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex","name":"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex - Osmosis Blog","isPartOf":{"@id":"https:\/\/www.osmosis.org\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage"},"image":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage"},"thumbnailUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp","datePublished":"2021-01-27T00:11:00+00:00","dateModified":"2025-10-01T19:45:05+00:00","breadcrumb":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#primaryimage","url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp","contentUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp","width":1081,"height":1080,"caption":"USMLE\u00ae Step 1 Question: Human Leukocyte Antigen Complex"},{"@type":"BreadcrumbList","@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-human-leukocyte-antigen-complex#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.osmosis.org\/blog"},{"@type":"ListItem","position":2,"name":"USMLE\u00ae Step 1 Question of the Day: Human Leukocyte Antigen Complex"}]},{"@type":"WebSite","@id":"https:\/\/www.osmosis.org\/blog\/#website","url":"https:\/\/www.osmosis.org\/blog\/","name":"Osmosis Blog","description":"","publisher":{"@id":"https:\/\/www.osmosis.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.osmosis.org\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.osmosis.org\/blog\/#organization","name":"Osmosis Blog","url":"https:\/\/www.osmosis.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png","contentUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png","width":1276,"height":596,"caption":"Osmosis Blog"},"image":{"@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc","name":"Marina Horiates Kerekes, MD &amp; Team","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g","caption":"Marina Horiates Kerekes, MD &amp; Team"},"description":"Authors: Marina Horiates Kerekes, MD &amp; Osmosis Question Writing Team","url":"https:\/\/www.osmosis.org\/blog\/author\/marinahoriateskerekesandteam"}]}},"jetpack_featured_media_url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-11T181141.939.webp","jetpack-related-posts":[{"id":3441,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis","url_meta":{"origin":2328,"position":0},"title":"USMLE\u00ae Step 1 Question of the Day: Urethritis","author":"Marina Horiates Kerekes, MD &amp; Team","date":"December 22, 2021","format":false,"excerpt":"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today's case focuses on a 26-year-old man with penile discharge and urination pain after engaging in unprotected sexual intercourse.\u00a0Can you figure it out? A 26-year-old man presents to his primary care physician with\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE\u00ae Step 1 Question of the Day: Urethritis","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-18T132226.154.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-18T132226.154.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-18T132226.154.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-18T132226.154.webp 2x"},"classes":[]},{"id":1403,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-excessive-fatigue-and-constipation","url_meta":{"origin":2328,"position":1},"title":"USMLE\u00ae Step 1 Question of the Day: Excessive Fatigue and Constipation","author":"Marina Horiates Kerekes, MD &amp; Team","date":"July 6, 2022","format":false,"excerpt":"This week, we are sharing another USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics.\u00a0Today's case involves a 41-year-old woman with excessive fatigue and constipation. Can you figure it out? A 41-year-old woman comes to the physician complaining of excessive fatigue for the last 2 weeks. She\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-excessive-fatigue-constipation.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-excessive-fatigue-constipation.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-excessive-fatigue-constipation.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-excessive-fatigue-constipation.webp 2x"},"classes":[]},{"id":9426,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-dysuria","url_meta":{"origin":2328,"position":2},"title":"USMLE\u00ae Step 2 CK Question of the Day:\u00a0Dysuria","author":"Rowan Bell, MD &amp; Marina Horiates Kerekes, MD","date":"March 23, 2026","format":false,"excerpt":"Follow the case of a 30-year-old woman with four days of dysuria, urgency, and suprapubic tenderness as clinicians review history, exam findings, and urinalysis results to navigate the differential and why certain tests guide decision-making.","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE Step 2 Question of the Day: Dysuria","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/03\/USMLE-step-2-question-of-the-day-dysuria.jpg","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/03\/USMLE-step-2-question-of-the-day-dysuria.jpg 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/03\/USMLE-step-2-question-of-the-day-dysuria.jpg 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/03\/USMLE-step-2-question-of-the-day-dysuria.jpg 2x"},"classes":[]},{"id":648,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-frequent-urination-diagnosis","url_meta":{"origin":2328,"position":3},"title":"USMLE\u00ae Step 1 Question of the Day: Frequent Urination Diagnosis","author":"Marina Horiates Kerekes, MD &amp; Team","date":"January 13, 2021","format":false,"excerpt":"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today's case involves a young boy whose worsening issues with thirst and frequent urination are worrying his parents. Can you make the correct diagnosis and help this family out? An 8-year-old boy is\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE\u00ae Step 1 Question of the Day: Frequent Urination Diagnosis","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/25.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/25.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/25.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/25.webp 2x"},"classes":[]},{"id":2073,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-gonorrhea","url_meta":{"origin":2328,"position":4},"title":"USMLE\u00ae Step 1 Question of the Day: Gonorrhea","author":"Marina Horiates Kerekes, MD &amp; Team","date":"February 8, 2023","format":false,"excerpt":"This week, we are sharing another USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics.\u00a0Today's case involves a 22-year-old woman who was diagnosed with herpes simplex genital infection two months ago.\u00a0Speculum examination reveals mucopurulent discharge and a friable erythematous cervix. Cervical motion tenderness is absent. Which of\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE\u00ae Step 1 Question of the Day: Gonorrhea","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/95.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/95.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/95.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/95.webp 2x"},"classes":[]},{"id":3932,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-2-question-of-the-day-hiv-positive","url_meta":{"origin":2328,"position":5},"title":"USMLE\u00ae Step 2 Question of the Day: HIV positive","author":"Marina Horiates Kerekes, MD &amp; Team","date":"June 26, 2024","format":false,"excerpt":"Explore a crucial aspect of HIV management with this scenario-based\u00a0USMLE Step 2 CK\u00a0question. Learn about recommended screening tests for newly diagnosed HIV-positive patients. A 32-year-old biologically female patient presents to the primary care office for an initial visit after learning she is HIV-positive from a screening test. The patient does\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-hiv-positive.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-hiv-positive.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-hiv-positive.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-hiv-positive.webp 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/2328","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/users\/202"}],"replies":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/comments?post=2328"}],"version-history":[{"count":5,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/2328\/revisions"}],"predecessor-version":[{"id":8321,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/2328\/revisions\/8321"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/media\/2329"}],"wp:attachment":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/media?parent=2328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/categories?post=2328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/tags?post=2328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}