{"id":3415,"date":"2021-07-14T18:43:00","date_gmt":"2021-07-14T18:43:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=3415"},"modified":"2025-10-01T11:42:40","modified_gmt":"2025-10-01T19:42:40","slug":"usmle-step-1-question-of-the-day-migraine-headaches","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches","title":{"rendered":"USMLE\u00ae Step 1 Question of the Day: Migraine Headaches"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\" >The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#D_Activation_of_serotonin_receptors\" >D. Activation of serotonin receptors<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#Incorrect_answer_explanations\" >Incorrect answer explanations<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#A_Inhibition_of_H1_receptors\" >A. Inhibition of H1&nbsp;receptors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#B_Inhibition_of_serotonin_and_norepinephrine_reuptake_from_the_synaptic_cleft\" >B.&nbsp;Inhibition of serotonin and norepinephrine reuptake&nbsp;from the synaptic cleft<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#C_Activation_of_somatostatin_receptors\" >C. Activation of&nbsp;somatostatin&nbsp;receptors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#E_Inhibition_of_calcium_channels_in_vascular_smooth_muscle_cells\" >E. Inhibition of calcium channels in vascular smooth muscle cells<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#Main_Explanation\" >Main Explanation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#Major_Takeaway\" >Major Takeaway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><strong><em>Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a 25-year-old woman with a severe headache. Can you figure it out?<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 25-year-old woman comes to the emergency department because of a severe headache that began four hours ago. She describes the pain as pulsating and localized to the area above her left eye. She denies any nausea or vomiting. She tried an over-the-counter non-steroidal anti-inflammatory medication at home, which provided no relief. The patient receives another first-line medication for her condition and her symptoms soon resolve. This medication works by which of the following mechanisms of action?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Inhibition of H<sub>1&nbsp;<\/sub>receptors<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Inhibition of serotonin and norepinephrine reuptake from the synaptic cleft<br>C. Activation of somatostatin receptors<br>D. Activation of serotonin receptors<br>E. Inhibition of calcium channels in vascular smooth muscle cells<\/strong><strong><br><\/strong>Scroll down to find the answer!<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Everybody loves Osmosis.org\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/kizbJZ9cdLg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong><em><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><u><em><strong>\u2192 Reinforce your understanding with more self-assessment items on Osmosis.<\/strong>\u00a0<\/em><\/u><\/a><\/em><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"D_Activation_of_serotonin_receptors\"><\/span>D. Activation of serotonin receptors<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Before we get to the&nbsp;<strong>Main Explanation<\/strong>, let&#8217;s look at the incorrect answer explanations. Skip to the bottom if you want to see the correct answer right away!<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_answer_explanations\"><\/span>Incorrect answer explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The incorrect answers to today&#8217;s USMLE\u00ae Step 1 Question are&#8230;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"A_Inhibition_of_H1_receptors\"><\/span>A. Inhibition of H<sub>1&nbsp;<\/sub>receptors<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>This is the mechanism of action of&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Antihistamines_for_allergies\" target=\"_blank\" rel=\"noreferrer noopener\">antihistamines<\/a>&nbsp;such as diphenhydramine, commonly used to treat allergies and motion sickness. It can also be used in an acute&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Migraine\" target=\"_blank\" rel=\"noreferrer noopener\">migraine attack<\/a>&nbsp;associated with nausea and vomiting, but this patient denies these symptoms.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B_Inhibition_of_serotonin_and_norepinephrine_reuptake_from_the_synaptic_cleft\"><\/span>B.&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Serotonin_and_norepinephrine_reuptake_inhibitors\" target=\"_blank\" rel=\"noreferrer noopener\">Inhibition of serotonin and norepinephrine reuptake<\/a>&nbsp;from the synaptic cleft<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;This is the proposed mechanism of action of amitriptyline, a&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Tricyclic_antidepressants\" target=\"_blank\" rel=\"noreferrer noopener\">tricyclic antidepressant<\/a>&nbsp;which is often used in peripheral neuropathy, chronic pain, resistant&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Major_depressive_disorder\" target=\"_blank\" rel=\"noreferrer noopener\">depression<\/a>&nbsp;and migraine prophylaxis. However, it is not used for migraines during the acute phase.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"C_Activation_of_somatostatin_receptors\"><\/span>C. Activation of&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Somatostatin\" target=\"_blank\" rel=\"noreferrer noopener\">somatostatin<\/a>&nbsp;receptors<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;This is the mechanism of action of octreotide, a somatostatin analogue that is used to treat&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Acromegaly\" target=\"_blank\" rel=\"noreferrer noopener\">acromegaly<\/a>,&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Gigantism\" target=\"_blank\" rel=\"noreferrer noopener\">gigantism<\/a>, thyrotropinoma,&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Carcinoid_tumor\" target=\"_blank\" rel=\"noreferrer noopener\">carcinoid syndrome<\/a>, and vasoactive intestinal peptide-secreting tumors (VIPomas). It has also shown to be effective at relieving acute&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Cluster_headache\" target=\"_blank\" rel=\"noreferrer noopener\">cluster headaches<\/a>, but not&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Migraine\" target=\"_blank\" rel=\"noreferrer noopener\">migraine headaches<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"E_Inhibition_of_calcium_channels_in_vascular_smooth_muscle_cells\"><\/span>E. Inhibition of calcium channels in vascular smooth muscle cells<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>This is the mechanism of action of verapamil, which is commonly used as prophylactic treatment for cluster headaches. It is not used to treat acute&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Migraine\" target=\"_blank\" rel=\"noreferrer noopener\">migraine attacks<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Explanation\"><\/span><strong>Main Explanation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This patient&#8217;s presentation of pulsatile, unilateral headache is consistent with a&nbsp;<strong><a href=\"https:\/\/www.osmosis.org\/learn\/Migraine\" target=\"_blank\" rel=\"noreferrer noopener\">migraine<\/a><\/strong>.&nbsp;<strong>Triptans<\/strong>, specifically&nbsp;<strong>sumatriptan<\/strong>, are used as<strong>&nbsp;first<\/strong>&#8211;<strong>lineabortive therapy<\/strong>&nbsp;for migraines after over-the-counter non-steroidal anti-inflammatories (<a href=\"https:\/\/www.osmosis.org\/learn\/Non-steroidal_anti-inflammatory_drugs\" target=\"_blank\" rel=\"noreferrer noopener\">NSAIDs<\/a>) have failed. Sumatriptan is a&nbsp;<strong>serotonin (5-HT<sub>1B\/1D<\/sub>) agonist<\/strong>. The drug binds to serotonin receptors in the brain, triggering vasoconstriction, inhibition of trigeminal nerve activation (thought to be the cause of migraine pain), and decreased vasoactive peptide release (reducing inflammation). It can be administered orally, subcutaneously, or intranasally, and reaches peak blood concentration in approximately 15 minutes (faster than any other migraine-specific medication). Triptans may cause adverse effects including&nbsp;<strong>coronary artery vasospasm<\/strong>, mild paresthesias, and&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Serotonin_syndrome\" target=\"_blank\" rel=\"noreferrer noopener\">serotonin syndrome<\/a>&nbsp;(in combination with other 5-HT agonists). Therefore, they are&nbsp;<strong>contraindicated<\/strong>&nbsp;in patients with a history of ischemic, cardiac, cerebrovascular, or peripheral vascular disease, uncontrolled hypertension, and in women who are pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Major_Takeaway\"><\/span><strong>Major Takeaway<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Triptans, specifically&nbsp;<strong>sumatriptan<\/strong>, are used as first-line abortive therapy for&nbsp;<strong><a href=\"https:\/\/www.osmosis.org\/learn\/Migraine\" target=\"_blank\" rel=\"noreferrer noopener\">migraine headaches<\/a><\/strong>&nbsp;after over-the-counter non-steroidal anti-inflammatories have failed. It works by&nbsp;<strong>activating serotonin (5-HT<\/strong><strong><sub>1B\/1D<\/sub><\/strong><strong>) receptors&nbsp;<\/strong>in the central nervous system.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span><strong>References<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology [published correction appears in Neurology 2000 Jan 9;56(1):142].&nbsp;<em>Neurology<\/em>. 2000;55(6):754\u2010762. doi:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10993991\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1212\/wnl.55.6.754<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Colman I, Brown MD, Innes GD, Grafstein E, Roberts TE, Rowe BH. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials.&nbsp;<em>BMJ<\/em>. 2004;329(7479):1369\u20101373. doi:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC535449\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1136\/bmj.38281.595718.7<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>_________________________<\/strong><br><br><strong>Want more USMLE\u00ae Step 1 practice questions? Try Osmosis today! Access your&nbsp;<a href=\"https:\/\/www.osmosis.org\/login?type=create\" target=\"_blank\" rel=\"noreferrer noopener\">free trial<\/a>&nbsp;and find out why millions of current and future clinicians and caregivers love learning with us.<\/strong><\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_1ccac0.png?w=700\" alt=\"\" class=\"wp-image-3360\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_1ccac0.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_1ccac0.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em><sub>The United States Medical Licensing Examination (USMLE\u00ae) is a joint program of the Federation of State Medical Boards (FSMB\u00ae) and National Board of Medical Examiners (NBME\u00ae). Osmosis is not affiliated with NBME nor FSMB.&nbsp;<\/sub><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a 25-year-old woman with a severe headache. Can you figure it out? A 25-year-old woman comes to the emergency department because of a severe headache that began four hours ago. She describes the pain as [&hellip;]<\/p>\n","protected":false},"author":202,"featured_media":3416,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[27,20,1369,44],"tags":[],"class_list":["post-3415","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-exam-prep","category-step-1-questions","category-step-1"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>USMLE\u00ae Step 1 Question of the Day: Migraine Headaches - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USMLE\u00ae Step 1 Question of the Day: Migraine Headaches - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case involves a 25-year-old woman with a severe headache. Can you figure it out? A 25-year-old woman comes to the emergency department because of a severe headache that began four hours ago. She describes the pain as [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\" \/>\n<meta property=\"og:site_name\" content=\"Osmosis Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-14T18:43:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-01T19:42:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-migraine-headaches.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1081\" \/>\n\t<meta property=\"og:image:height\" content=\"1081\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Marina Horiates Kerekes, MD &amp; Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-migraine-headaches\"},\"author\":{\"name\":\"Marina Horiates Kerekes, MD &amp; 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Today's case involves a young woman who is experiencing unilateral headaches with photophobia. Can you prescribe a medication to help her feel better? 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What side effects should clinicians monitor for during continuous therapy?","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE\u00ae Step 1 Question of the Day:\u00a0Endometriosis medication","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/11\/Endometriosis_meds_Blog.png","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/11\/Endometriosis_meds_Blog.png 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/11\/Endometriosis_meds_Blog.png 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/11\/Endometriosis_meds_Blog.png 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/3415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/users\/202"}],"replies":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/comments?post=3415"}],"version-history":[{"count":3,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/3415\/revisions"}],"predecessor-version":[{"id":6741,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/3415\/revisions\/6741"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/media\/3416"}],"wp:attachment":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/media?parent=3415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/categories?post=3415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/tags?post=3415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}