{"id":3441,"date":"2021-12-22T19:22:00","date_gmt":"2021-12-22T19:22:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=3441"},"modified":"2025-10-01T11:40:34","modified_gmt":"2025-10-01T19:40:34","slug":"usmle-step-1-question-of-the-day-urethritis","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis","title":{"rendered":"USMLE\u00ae Step 1 Question of the Day: Urethritis"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\" >The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#A_Positive_leukocyte_esterase_with_no_bacteria\" >A. Positive leukocyte esterase with no bacteria<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#Incorrect_answer_explanations\" >Incorrect answer explanations<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#B_Positive_leukocyte_esterase_and_positive_nitrite\" >B. Positive leukocyte esterase and positive nitrite<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#C_High_white_blood_cell_count_and_hyaline_casts\" >C. High white blood cell count and hyaline casts<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#D_Urine_pH_85\" >D. Urine pH 8.5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#E_Red_blood_cells_and_positive_leukocyte_esterase\" >E. Red blood cells and positive leukocyte esterase<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#Main_Explanation\" >Main Explanation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#Major_Takeaway\" >Major Takeaway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case focuses on a 26-year-old man with penile discharge and urination pain after engaging in unprotected sexual intercourse.&nbsp;<\/em><\/strong><strong><em>Can you figure it out?<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 26-year-old man presents to his primary care physician with penile discharge. He also reports experiencing pain with urination starting 3 days ago. Last weekend, he engaged in unprotected sexual intercourse with a new female partner. His vital signs are 37 \u00b0C (98.6.\u00b0F), pulse is 67\/min, respirations are 14\/min, blood pressure is 126\/74 mmHg, and oxygen saturation is 99% on room air. Physical examination shows mucoid discharge at the urethral meatus. Which of the following laboratory findings is most likely to be observed in this patient?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Positive leukocyte esterase with no bacteria<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Positive leukocyte esterase and positive nitrite<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. High white blood cell count and hyaline casts<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. Urine pH 8.5<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. Red blood cells and positive leukocyte esterase<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Scroll down to find the answer!<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Everybody loves Osmosis.org\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/kizbJZ9cdLg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><u><em><strong>\u2192 Reinforce your understanding with more self-assessment items on Osmosis.<\/strong>\u00a0<\/em><\/u><\/a><\/em><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"A_Positive_leukocyte_esterase_with_no_bacteria\"><\/span>A. Positive leukocyte esterase with no bacteria<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Before we get to the&nbsp;<strong>Main Explanation<\/strong>, let&#8217;s look at the incorrect answer explanations. Skip to the bottom if you want to see the correct answer right away!<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_answer_explanations\"><\/span>Incorrect answer explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The incorrect answers to today&#8217;s USMLE\u00ae Step 1 Question are&#8230;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B_Positive_leukocyte_esterase_and_positive_nitrite\"><\/span>B. Positive leukocyte esterase and positive nitrite<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>Positive leukocyte esterase and positive nitrite are more consistent with cystitis or pyelonephritis, which are most often caused by&nbsp;<em><a href=\"https:\/\/www.osmosis.org\/learn\/Escherichia_coli\" target=\"_blank\" rel=\"noreferrer noopener\">Escherichia coli<\/a><\/em>.&nbsp;<a href=\"https:\/\/www.osmosis.org\/notes\/Genitourinary_tract_infections#page-1\" target=\"_blank\" rel=\"noreferrer noopener\">Urethritis<\/a>&nbsp;is more commonly caused by&nbsp;<em><a href=\"https:\/\/www.osmosis.org\/learn\/Neisseria_gonorrhoeae\" target=\"_blank\" rel=\"noreferrer noopener\">Neisseria gonorrhea<\/a><\/em>&nbsp;or&nbsp;<em><a href=\"https:\/\/www.osmosis.org\/learn\/Chlamydia_trachomatis\" target=\"_blank\" rel=\"noreferrer noopener\">Chlamydia trachomatis<\/a><\/em>, which are non-nitrite producing organisms.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"C_High_white_blood_cell_count_and_hyaline_casts\"><\/span>C. High white blood cell count and hyaline casts<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>A high white blood cell count is not usually seen with lower&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Urinary_tract_infections:_Pathology_review\" target=\"_blank\" rel=\"noreferrer noopener\">urinary tract infections<\/a>&nbsp;but is more commonly seen in the setting of pyelonephritis. Hyaline casts may also be observed in pyelonephritis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"D_Urine_pH_85\"><\/span>D. Urine pH 8.5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>Alkaline urine is more commonly seen with infectious organisms such as&nbsp;<em><a href=\"https:\/\/www.osmosis.org\/learn\/Proteus_mirabilis\" target=\"_blank\" rel=\"noreferrer noopener\">Proteus mirabilis<\/a><\/em>, a common culprit in patients with&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Chronic_pyelonephritis\" target=\"_blank\" rel=\"noreferrer noopener\">chronic pyelonephritis<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"E_Red_blood_cells_and_positive_leukocyte_esterase\"><\/span>E. Red blood cells and positive leukocyte esterase<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:&nbsp;<\/strong>These urinalysis findings are more commonly found in the setting of nephrolithiasis, which presents with lancinating flank radiating to the groin, nausea, and vomiting.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.osmosis.org\/plans\/md\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_b69893.png\" alt=\"Osmosis ad to create an account\" class=\"wp-image-3443\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_b69893.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_b69893.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Explanation\"><\/span><strong>Main Explanation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This young male patient, who is presenting with&nbsp;<strong>penile discharge&nbsp;<\/strong>and&nbsp;<strong>dysuria<\/strong>&nbsp;in the setting of recent unprotected sexual intercourse, likely has&nbsp;<strong><a href=\"https:\/\/www.osmosis.org\/notes\/Genitourinary_tract_infections#page-1\" target=\"_blank\" rel=\"noreferrer noopener\">urethritis<\/a><\/strong>. Of the laboratory abnormalities listed, urinalysis with positive leukocyte esterase and no bacteria is most likely consistent with&nbsp;<strong>sterile pyuria<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Urethritis refers to inflammation of the urethra. Clinically, it is difficult to distinguish from&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Lower_urinary_tract_infection\" target=\"_blank\" rel=\"noreferrer noopener\">cystitis<\/a>&nbsp;(bladder inflammation), since it presents with many similar symptoms including dysuria or discharge at the urethral meatus. However, urethritis can be differentiated clinically from&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Acute_pyelonephritis\" target=\"_blank\" rel=\"noreferrer noopener\">pyelonephritis<\/a>, based on absence of systemic features including fever, tachycardia, costovertebral angle tenderness, nausea, and vomiting.Urethritis can be further differentiated from other urinary tract infections based on the causative organisms and laboratory findings. In general, the majority of urethral infections are caused by sexuallay transmitted organisms, such as&nbsp;<strong><a href=\"https:\/\/www.osmosis.org\/learn\/Chlamydia_trachomatis\"><\/a><em><a href=\"https:\/\/www.osmosis.org\/learn\/Chlamydia_trachomatis\" target=\"_blank\" rel=\"noreferrer noopener\">Chlamydia trachomatis<\/a><\/em><\/strong>&nbsp;and&nbsp;<strong><a href=\"https:\/\/www.osmosis.org\/learn\/Neisseria_gonorrhoeae\"><\/a><em><a href=\"https:\/\/www.osmosis.org\/learn\/Neisseria_gonorrhoeae\" target=\"_blank\" rel=\"noreferrer noopener\">Neisseria gonorrhoeae<\/a><\/em><\/strong>. A urinalysis will reveal sterile pyuria, which refers to positive leukocyte esterase without identifiable bacteria on microscopy. Confirmatory diagnosis relies on urethral swabs with subsequent&nbsp;<strong>nucleic acid amplification<\/strong>&nbsp;testing, in addition to possible Gram-staining for&nbsp;<strong><em><a href=\"https:\/\/www.osmosis.org\/learn\/Neisseria_gonorrhoeae\" target=\"_blank\" rel=\"noreferrer noopener\">Neisseria gonorrhea<\/a>.<\/em><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Urinary tract infections ~high yield~\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/-h8HcikOCao?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Major_Takeaway\"><\/span><strong>Major Takeaway<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Urethritis refers to inflammation of the urethra. It is commonly caused by sexuallly transmitted infections from&nbsp;<strong><em><a href=\"https:\/\/www.osmosis.org\/learn\/Chlamydia_trachomatis\" target=\"_blank\" rel=\"noreferrer noopener\">Chlamydia trachomatis<\/a><\/em><\/strong>&nbsp;and&nbsp;<strong><em><a href=\"https:\/\/www.osmosis.org\/learn\/Neisseria_gonorrhoeae\" target=\"_blank\" rel=\"noreferrer noopener\">Neisseria gonorrhoeae<\/a><\/em><\/strong><em>,<\/em><strong>&nbsp;<\/strong>and it demonstrates sterile pyuria in urinalysis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span><strong>References<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Curry, M. (2017, May 18). Rosen&#8217;s Emergency Medicine: Concepts and Clinical Practice. Retrieved from&nbsp;<a href=\"https:\/\/www.us.elsevierhealth.com\/rosens-emergency-medicine-concepts-and-clinical-practice-9780323354790.html\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.us.elsevierhealth.com\/rosens-emergency-medicine-concepts-and-clinical-practice-9780323354790.html<\/a>. ISBN: 0323354793<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 2015; 64:1. doi:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26602614\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.15585\/mmwr.rr6805a1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Taylor SN, Liesenfeld O, Lillis RA, et al. Evaluation of the Roche cobas\u00ae CT\/NG test for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in male urine. Sex Transm Dis 2012; 39:543. doi:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22706217\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1097\/OLQ.0b013e31824e26ff.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>_________________________<\/strong><br><br><strong>Want more USMLE\u00ae Step 1 practice questions? Try Osmosis today! Access your&nbsp;<em><strong><a href=\"https:\/\/www.osmosis.org\/login?type=create\" target=\"_blank\" rel=\"noreferrer noopener\">free trial<\/a><\/strong><\/em>&nbsp;and find out why millions of current and future clinicians and caregivers love learning with us.<\/strong><\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.osmosis.org\/ultimate-guide\/usmle-step-1\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_a3c802.png\" alt=\"The ultimate guide to the USMLE Step 1: everything you need to know read now button.\" class=\"wp-image-3444\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_a3c802.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_a3c802.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.osmosis.org\/ultimate-guide\/usmle-step-1\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><em><sub>The United States Medical Licensing Examination (USMLE\u00ae) is a joint program of the Federation of State Medical Boards (FSMB\u00ae) and National Board of Medical Examiners (NBME\u00ae). Osmosis is not affiliated with NBME nor FSMB.&nbsp;<\/sub><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case focuses on a 26-year-old man with penile discharge and urination pain after engaging in unprotected sexual intercourse.&nbsp;Can you figure it out? A 26-year-old man presents to his primary care physician with penile discharge. He also reports [&hellip;]<\/p>\n","protected":false},"author":202,"featured_media":3442,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[27,20,1369,44],"tags":[],"class_list":["post-3441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-exam-prep","category-step-1-questions","category-step-1"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>USMLE\u00ae Step 1 Question of the Day: Urethritis - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USMLE\u00ae Step 1 Question of the Day: Urethritis - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today&#8217;s case focuses on a 26-year-old man with penile discharge and urination pain after engaging in unprotected sexual intercourse.&nbsp;Can you figure it out? A 26-year-old man presents to his primary care physician with penile discharge. He also reports [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\" \/>\n<meta property=\"og:site_name\" content=\"Osmosis Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-12-22T19:22:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-01T19:40:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/2024-09-18T132226.154.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1081\" \/>\n\t<meta property=\"og:image:height\" content=\"1081\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Marina Horiates Kerekes, MD &amp; Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-urethritis\"},\"author\":{\"name\":\"Marina Horiates Kerekes, MD &amp; 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