{"id":3896,"date":"2022-08-10T13:08:00","date_gmt":"2022-08-10T13:08:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=3896"},"modified":"2025-10-01T11:40:34","modified_gmt":"2025-10-01T19:40:34","slug":"usmle-step-2-ck-question-of-the-day-prolactinoma","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma","title":{"rendered":"USMLE\u00ae Step 2 CK Question of the Day: Prolactinoma"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#The_correct_answer_to_todays_USMLE%C2%AE_Step_2_CK_Question_is%E2%80%A6\" >The correct answer to today&#8217;s USMLE\u00ae Step 2 CK Question is&#8230;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#D_Bromocriptine\" >D. Bromocriptine<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#Incorrect_answer_explanations\" >Incorrect answer explanations<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#A_Transsphenoidal_surgical_resection\" >A. Transsphenoidal surgical resection<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#B_Weight_gain\" >B. Weight gain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#C_Octreotide\" >C. Octreotide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#E_Estrogen_supplementation\" >E. Estrogen supplementation<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#Main_Explanation\" >Main Explanation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#Major_Takeaway\" >Major Takeaway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><em><strong>Here&#8217;s another USMLE\u00ae Step 2 CK Question of the Day!\u00a0Today&#8217;s case involves a\u00a025-year-old woman with amenorrhea and white discharge from her breasts. Can you figure it out?<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 25-year-old woman comes to her primary care physician because of a six-month history of\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Amenorrhea:_Clinical_practice\" target=\"_blank\" rel=\"noreferrer noopener\">amenorrhea<\/a>. The patient previously had regular menstrual cycles at 30-day intervals. In addition, she has noticed scant white discharge from the breasts bilaterally. Past medical history is notable for\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Asthma:_Clinical_practice\" target=\"_blank\" rel=\"noreferrer noopener\">asthma<\/a>, for which she takes albuterol occasionally. Temperature is 37.3\u00b0C (99.1\u00b0F), pulse is 80\/min, respirations are 20\/min, and blood pressure is 118\/77 mmHg. BMI is 20 kg\/m<sup>2<\/sup>. Physical examination is unremarkable. Quantitative beta-HCG is negative. Radiographic imaging reveals the following findings:<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"257\" height=\"241\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/radiographic-imaging-of-skull.jpg\" alt=\"Radiographic imaging of skull\" class=\"wp-image-3899\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Image reproduced from&nbsp;<a href=\"https:\/\/radiopaedia.org\/cases\/pituitary-adenoma-1?lang=us\" target=\"_blank\" rel=\"noreferrer noopener\">Radiopedia<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Laboratory testing reveals serum&nbsp;<a href=\"https:\/\/www.osmosis.org\/learn\/Oxytocin_and_prolactin\" target=\"_blank\" rel=\"noreferrer noopener\">prolactin&nbsp;<\/a>of 320 ng\/mL (normal &lt;25 ng\/ml in non-pregnant females). Which of the following is the next best step in the management of this patient?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Transsphenoidal surgical resection<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Weight gain<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Octreotide<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. Bromocriptine<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. Estrogen supplementation<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Scroll down for the correct answer!<\/p>\n\n\n\n<figure class=\"wp-block-embed aligncenter is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Uzbekistan learns by Osmosis.org!\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/qhStIrZaFT4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\"><strong>Check out our free<a href=\"https:\/\/www.osmosis.org\/ultimate-guide\/usmle-step-2\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;USMLE\u00ae Step 2 Ultimate Guide!<\/a><\/strong><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_USMLE%C2%AE_Step_2_CK_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s USMLE\u00ae Step 2 CK Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"D_Bromocriptine\"><\/span>D. Bromocriptine<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Before we get to the&nbsp;<strong>Main Explanation<\/strong>, let&#8217;s see why the answer wasn&#8217;t A, B, C, or E. Skip to the bottom if you want to see the correct answer right away!<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_answer_explanations\"><\/span>Incorrect answer explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Today&#8217;s incorrect answers are&#8230;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"A_Transsphenoidal_surgical_resection\"><\/span>A. Transsphenoidal surgical resection<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>\u00a0This patient has a\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Prolactinoma\" target=\"_blank\" rel=\"noreferrer noopener\">prolactinoma<\/a>. First-line treatment consists of dopamine agonists, such as bromocriptine and cabergoline. Surgical intervention is generally indicated only in patients who have failed medical therapy or are unable to tolerate medication side effects.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B_Weight_gain\"><\/span>B. Weight gain<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;Patients with a low BMI may develop amenorrhea because the low body weight shuts down GnRH secretion by the hypothalamus. However, this patient has a BMI of 20 kg\/m<sup>2<\/sup>, which is within normal limits.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"C_Octreotide\"><\/span>C. Octreotide<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;Octreotide is a somatostatin analogue that can be used to treat acromegaly and neuroendocrine tumors. However, the medication is not used in the treatment of prolactinomas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"E_Estrogen_supplementation\"><\/span>E. Estrogen supplementation<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>\u00a0Estrogen supplementation can be used to treat\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Menopause\" target=\"_blank\" rel=\"noreferrer noopener\">menopausal symptoms<\/a>\u00a0and ovarian insufficiency. This patient likely has lowered\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Estrogen_and_progesterone\" target=\"_blank\" rel=\"noreferrer noopener\">estrogen\u00a0<\/a>levels secondary to a prolactin-secreting adenoma since prolactin inhibits GnRH production. As such, treatment should be geared at addressing the underlying cause as opposed to merely repleting estrogen levels.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/ace-your-clerkship-banner-2.png?w=700\" alt=\"Ace your clerkships with clinical practice videos on Osmosis. Watch now.\" class=\"wp-image-544\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/ace-your-clerkship-banner-2.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/ace-your-clerkship-banner-2.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Explanation\"><\/span><strong>Main Explanation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The clinical presentation of\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Amenorrhea:_Clinical_practice\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amenorrhea<\/strong>\u00a0<\/a>and\u00a0<strong>galactorrhea<\/strong>, together with significantly<strong>\u00a0elevated serum prolactin<\/strong>\u00a0and MRI findings of a well-defined\u00a0<strong>homogeneously enhancing lesion<\/strong>\u00a0in the\u00a0<strong>pituitary fossa,<\/strong>\u00a0are highly suggestive of a\u00a0<strong><a href=\"https:\/\/www.osmosis.org\/learn\/Prolactinoma\" target=\"_blank\" rel=\"noreferrer noopener\">prolactinoma<\/a><\/strong>, a prolactin-secreting\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Pituitary_adenoma\" target=\"_blank\" rel=\"noreferrer noopener\">pituitary adenoma<\/a>. The condition can cause infertility, galactorrhea, and mass effect (e.g., compression of the optic chiasm resulting in bitemporal hemianopsia). In women, this condition can also cause amenorrhea, vaginal dryness, and increased risk of\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Osteoporosis\" target=\"_blank\" rel=\"noreferrer noopener\">osteoporosis<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Prolactinoma - causes, symptoms, diagnosis, treatment, pathology\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/8gH3aYa4y7Q?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Work-up involves measuring\u00a0<strong>blood prolactin levels<\/strong>. Adenomas 1.0-2.0 cm in diameter are typically associated with prolactin levels between 200 and 1000 ng\/mL and those greater than 2.0 cm in diameter with values above 1000 ng\/mL.\u00a0Brain MRI\u00a0is also performed to determine the tumor\u2019s size and location. First-line treatment consists of\u00a0dopamine agonists, such as cabergoline or bromocriptine, which reduce prolactin secretion.\u00a0Surgical resection\u00a0can be considered if the patient has failed dopamine agonist treatment or is unable to tolerate its side effects.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" height=\"441\" width=\"1024\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/pituatary-tumor.png?w=1024\" alt=\"Pituitary tumor under the optic nerve.\" class=\"wp-image-3898\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/pituatary-tumor.png 1386w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/pituatary-tumor.png?resize=300,129 300w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/pituatary-tumor.png?resize=768,331 768w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/pituatary-tumor.png?resize=1024,441 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Major_Takeaway\"><\/span><strong>Major Takeaway<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.osmosis.org\/learn\/Prolactinoma\" target=\"_blank\" rel=\"noreferrer noopener\">Prolactinomas\u00a0<\/a>can cause infertility, galactorrhea,\u00a0<a href=\"https:\/\/www.osmosis.org\/learn\/Amenorrhea:_Clinical_practice\" target=\"_blank\" rel=\"noreferrer noopener\">amenorrhea<\/a>, and mass effects. Diagnosis is based on measuring\u00a0<strong>prolactin levels<\/strong>\u00a0and obtaining a\u00a0<strong>brain MRI<\/strong>. First-line treatment consists of\u00a0<strong>dopamine agonists<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span><strong>References<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Dobri, G.A. (2020) \u201cProlactinoma\u201d.&nbsp;<em>National Organization for Rare Diseases<\/em>. Web Address:&nbsp;<a href=\"https:\/\/rarediseases.org\/rare-diseases\/prolactinoma\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/rarediseases.org\/rare-diseases\/prolactinoma\/.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Glezer, A., Bronstein, M.D. (2015) Prolactinomas.&nbsp;<em>Endocrinology and Metabolism Clinics of North America<\/em>. 44(1), 71-78. Doi:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25732643\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.ecl.2014.11.003.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013\u2013\u2013\u2013\u2013\u2013\u2013\u2013\u2013\u2013\u2013\u2013<em><br><strong>Want more &nbsp;USMLE\u00ae Step 2 CK practice questions?&nbsp;<\/strong><\/em><em><strong>Try Osmosis today!&nbsp;<\/strong><\/em><em><strong><a href=\"https:\/\/www.osmosis.org\/login?type=create\" target=\"_blank\" rel=\"noreferrer noopener\">Access your free trial<\/a><\/strong><\/em><em><strong>&nbsp;and find out why millions of current and future clinicians and caregivers love learning with us.<\/strong><\/em><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><a href=\"https:\/\/www.osmosis.org\/register\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"498\" height=\"178\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_8c6aaf.png?w=498\" alt=\"\" class=\"wp-image-3820\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_8c6aaf.png 498w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/image_8c6aaf.png?resize=300,107 300w\" sizes=\"auto, (max-width: 498px) 100vw, 498px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Here&#8217;s another USMLE\u00ae Step 2 CK Question of the Day!\u00a0Today&#8217;s case involves a\u00a025-year-old woman with amenorrhea and white discharge from her breasts. Can you figure it out? A 25-year-old woman comes to her primary care physician because of a six-month history of\u00a0amenorrhea. The patient previously had regular menstrual cycles at 30-day intervals. In addition, she [&hellip;]<\/p>\n","protected":false},"author":202,"featured_media":3897,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[27,20,45],"tags":[],"class_list":["post-3896","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-exam-prep","category-step-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>USMLE\u00ae Step 2 CK Question of the Day: Prolactinoma - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USMLE\u00ae Step 2 CK Question of the Day: Prolactinoma - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Here&#8217;s another USMLE\u00ae Step 2 CK Question of the Day!\u00a0Today&#8217;s case involves a\u00a025-year-old woman with amenorrhea and white discharge from her breasts. Can you figure it out? A 25-year-old woman comes to her primary care physician because of a six-month history of\u00a0amenorrhea. The patient previously had regular menstrual cycles at 30-day intervals. In addition, she [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\" \/>\n<meta property=\"og:site_name\" content=\"Osmosis Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-08-10T13:08:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-01T19:40:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/umsle-prolactinoma.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1081\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Marina Horiates Kerekes, MD &amp; Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-prolactinoma\"},\"author\":{\"name\":\"Marina Horiates Kerekes, MD &amp; 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