{"id":4776,"date":"2024-11-06T00:53:00","date_gmt":"2024-11-06T00:53:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=4776"},"modified":"2025-10-01T11:38:23","modified_gmt":"2025-10-01T19:38:23","slug":"usmle-step-1-question-of-the-day-histologic-analysis","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis","title":{"rendered":"USMLE\u00ae Step 1 Question of the Day: Histologic analysis"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\/#The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\" >The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\/#Incorrect_Answer_Explanations\" >Incorrect Answer Explanations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\/#Main_Explanation\" >Main Explanation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\/#Major_Takeaway\" >Major Takeaway<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\/#Want_to_learn_more_about_this_topic\" >Want to learn more about this topic?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><strong><em>Prepare for the USMLE Step 1 exam with this detailed question about a 57-year-old woman with malaise and intermittent fevers over the past several weeks.\u00a0Can you correctly identify which of the following findings is most likely to be demonstrated on histologic analysis?<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 57-year-old woman presents to her primary care physician with malaise and intermittent fevers over the past several weeks. She reports she was recently treated for a urinary tract infection, but her symptoms never completely improved. Her past medical history is significant for recurrent nephrolithiasis and type 2 diabetes mellitus. Her temperature is 38\u00b0C (100.4\u00b0F), pulse is 82\/min, respirations are 16\/min, blood pressure is 157\/64 mmHg, and oxygen saturation is 99% on room air. Physical examination shows left-sided costovertebral angle tenderness on palpation. If a biopsy of the kidney was to be performed, which of the following findings is most likely to be demonstrated on histologic analysis?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Which of the following structures at the neuromuscular junction is most likely affected in this patient\u2019s condition?\u00a0<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Eosinophilic casts<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Granulomatous tissue containing foamy macrophages<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Neutrophilic infiltrate of the renal interstitium<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. Polygonal clear cells filled with lipids and carbohydrate<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. Mesangial proliferation<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Scroll down for the correct answer!<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s USMLE\u00ae Step 1 Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Eosinophilic casts\u00a0\u00a0<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Before we get to the Main Explanation, let&#8217;s look at the incorrect answer explanations. Skip to the bottom if you want to see the correct answer right away!<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_Answer_Explanations\"><\/span>Incorrect Answer Explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Granulomatous tissue containing foamy macrophages&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;These histologic findings are more consistent with xanthogranulomatous pyelonephritis, which is a rare form of chronic pyelonephritis commonly due to&nbsp;Proteus mirabilis&nbsp;infection. This disease is much rarer than generalized chronic pyelonephritis.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Neutrophilic infiltrate of the renal interstitium&nbsp;<\/strong><strong>&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;These histologic findings are more consistent with acute pyelonephritis, which tends to present with acute onset nausea, vomiting, dysuria, and costovertebral angle tenderness.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. Polygonal clear cells filled with lipids and carbohydrate&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;These are the histologic findings associated with renal cell carcinoma, which typically manifests with hematuria, weight loss, and polycythemia.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. Mesangial proliferation<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong>&nbsp;These histologic findings are more consistent with IgA nephropathy, which is characterized by episodic hematuria that occurs concurrently with GI infection or upper respiratory infection due to the deposition of IgA in the mesangium.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Explanation\"><\/span>Main Explanation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/osmose-it.s3.amazonaws.com\/DeoUoyShRX_leIxlBu0jI4mcS-SxsDzu\/_.png\" alt=\"Histology slide (source: Wikipedia)\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This patient presents with chronic fevers, fatigue, and costovertebral angle tenderness in the setting of treatment failure for a urinary tract infection, consistent with&nbsp;chronic pyelonephritis. Her history is also notable for&nbsp;recurrent nephrolithiasis, which is a known risk factor for this condition.&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chronic pyelonephritis refers to the worsening kidney function and scarring that occurs in the setting of either recurrent urinary tract infections (most commonly), poorly treated urinary tract infections, an impaired vesicoureteral reflux mechanism, or chronically obstructing kidney stones. Gross specimens will demonstrate coarse, asymmetric corticomedullary scarring and blunted calyces. Renal tubules often contain&nbsp;eosinophilic casts&nbsp;which resemble thyroid tissue, coined&nbsp;thyroidization of the kidney.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Major_Takeaway\"><\/span>Major Takeaway<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.osmosis.org\/learn\/Chronic_pyelonephritis\" target=\"_blank\" rel=\"noreferrer noopener\">Chronic pyelonephritis<\/a>&nbsp;refers to worsening kidney function and scarring that occurs most commonly due to recurrent urinary tract infections. The major histologic finding is eosinophilic casts termed thyroidization of the kidney. &nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/osmose-it.s3.amazonaws.com\/qu6V_gcOTmyNItq1sN0EPxqRRxar-Fcz\/_.png\" alt=\"CHRONIC PYELONEPHRITIS\nThyroidization of the kidney\n* Highest yield\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Want_to_learn_more_about_this_topic\"><\/span>Want to learn more about this topic?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.osmosis.org\/learn\/Chronic_pyelonephritis\">Watch the Osmosis video: Chronic_pyelonephritis<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span>References<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Curry, M. (2017, May 18). Rosen&#8217;s Emergency Medicine: Concepts and Clinical Practice. Retrieved from&nbsp;<a href=\"https:\/\/www.us.elsevierhealth.com\/rosens-emergency-medicine-concepts-and-clinical-practice-9780323354790.html\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.us.elsevierhealth.com\/rosens-emergency-medicine-concepts-and-clinical-practice-9780323354790.html<\/a>. ISBN: 0323354793&nbsp;<\/li>\n\n\n\n<li>Urinary Tract Infection Syndromes Betsy Foxman PhD Infectious Disease Clinics of North America, 2014-03-01, Volume 28, Issue 1, Pages 1-13, doi: 10.1016\/j.idc.2013.09.003.&nbsp;<\/li>\n\n\n\n<li>International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Gupta%20K%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Gupta K<\/a>1,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Hooton%20TM%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Hooton TM<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Naber%20KG%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Naber KG<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Wullt%20B%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Wullt B<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Colgan%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Colgan R<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Miller%20LG%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Miller LG<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Moran%20GJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Moran GJ<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Nicolle%20LE%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Nicolle LE<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Raz%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Raz R<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Schaeffer%20AJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Schaeffer AJ<\/a>,&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Soper%20DE%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21292654\" target=\"_blank\" rel=\"noreferrer noopener\">Soper DE<\/a>;&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=Infectious%20Diseases%20Society%20of%20America%5BCorporate%20Author%5D\" target=\"_blank\" rel=\"noreferrer noopener\">Infectious Diseases Society of America<\/a>;&nbsp;<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=European%20Society%20for%20Microbiology%20and%20Infectious%20Diseases%5BCorporate%20Author%5D\" target=\"_blank\" rel=\"noreferrer noopener\">European Society for Microbiology and Infectious Diseases<\/a>.<a href=\"https:\/\/www-ncbi-nlm-nih-gov.ezproxy.galter.northwestern.edu\/pubmed\/?term=International+clinical+practice+guidelines+for+the+treatment+of+acute+uncomplicated+cystitis+and+pyelonephritis+in+women%3A+A+2010+update+by+the+Infectious+Diseases+Society+of+America+and+the+European+Society+for+Microbiology+and+Infectious+Diseases.+Clin+Infect+Dis+2011%3B+52%3Ae103.\" target=\"_blank\" rel=\"noreferrer noopener\">Clin Infect Dis.<\/a>&nbsp;2011 Mar 1;52(5):e103-20. doi: 10.1093\/cid\/ciq257<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.osmosis.org\/ultimate-guide\/usmle-step-1\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/osmose-it.s3.amazonaws.com\/IEVwkP8WQJe3hUkVpLPWPGOTRBqGDF-v\/_.png\" alt=\"Osmosis sign up ad\"\/><\/a><figcaption class=\"wp-element-caption\"><em><em><sub>The United States Medical Licensing Examination (USMLE\u00ae) is a joint program of the Federation of State Medical Boards (FSMB\u00ae) and National Board of Medical Examiners (NBME\u00ae). Osmosis is not affiliated with NBME nor FSMB.\u00a0<\/sub><\/em><\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Want more USMLE\u00ae Step 1 practice questions? Try Osmosis by Elsevier today! Access your&nbsp;<em><strong><a href=\"https:\/\/www.osmosis.org\/login?type=create\" target=\"_blank\" rel=\"noreferrer noopener\">free trial<\/a><\/strong><\/em>&nbsp;and discover why millions of current and future clinicians and caregivers love learning with us.<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prepare for the USMLE Step 1 exam with this detailed question about a 57-year-old woman with malaise and intermittent fevers over the past several weeks.\u00a0Can you correctly identify which of the following findings is most likely to be demonstrated on histologic analysis? A 57-year-old woman presents to her primary care physician with malaise and intermittent [&hellip;]<\/p>\n","protected":false},"author":202,"featured_media":4777,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[27,34,16,1366,1369,44],"tags":[],"class_list":["post-4776","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-omm","category-do","category-questions","category-step-1-questions","category-step-1"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>USMLE\u00ae Step 1 Question of the Day: Histologic analysis - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USMLE\u00ae Step 1 Question of the Day: Histologic analysis - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Prepare for the USMLE Step 1 exam with this detailed question about a 57-year-old woman with malaise and intermittent fevers over the past several weeks.\u00a0Can you correctly identify which of the following findings is most likely to be demonstrated on histologic analysis? A 57-year-old woman presents to her primary care physician with malaise and intermittent [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\" \/>\n<meta property=\"og:site_name\" content=\"Osmosis Blog\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-06T00:53:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-01T19:38:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png\" \/>\n\t<meta property=\"og:image:width\" content=\"826\" \/>\n\t<meta property=\"og:image:height\" content=\"823\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Marina Horiates Kerekes, MD &amp; Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\"},\"author\":{\"name\":\"Marina Horiates Kerekes, MD &amp; Team\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc\"},\"headline\":\"USMLE\u00ae Step 1 Question of the Day: Histologic analysis\",\"datePublished\":\"2024-11-06T00:53:00+00:00\",\"dateModified\":\"2025-10-01T19:38:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\"},\"wordCount\":769,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png\",\"articleSection\":[\"Allopathic Medicine (MD)\",\"OMM\",\"Osteopathic Medicine (DO)\",\"Questions of the Day\",\"USMLE Step 1\",\"USMLE\u00ae Step 1\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\",\"url\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\",\"name\":\"USMLE\u00ae Step 1 Question of the Day: Histologic analysis - Osmosis Blog\",\"isPartOf\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png\",\"datePublished\":\"2024-11-06T00:53:00+00:00\",\"dateModified\":\"2025-10-01T19:38:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage\",\"url\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png\",\"contentUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png\",\"width\":826,\"height\":823,\"caption\":\"A study tip titled USMLE Step 1 Question of the Day Histologic Analysis\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.osmosis.org\/blog\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"USMLE\u00ae Step 1 Question of the Day: Histologic analysis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#website\",\"url\":\"https:\/\/www.osmosis.org\/blog\/\",\"name\":\"Osmosis Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.osmosis.org\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#organization\",\"name\":\"Osmosis Blog\",\"url\":\"https:\/\/www.osmosis.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png\",\"contentUrl\":\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png\",\"width\":1276,\"height\":596,\"caption\":\"Osmosis Blog\"},\"image\":{\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc\",\"name\":\"Marina Horiates Kerekes, MD &amp; Team\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g\",\"caption\":\"Marina Horiates Kerekes, MD &amp; Team\"},\"description\":\"Authors: Marina Horiates Kerekes, MD &amp; Osmosis Question Writing Team\",\"url\":\"https:\/\/www.osmosis.org\/blog\/author\/marinahoriateskerekesandteam\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"USMLE\u00ae Step 1 Question of the Day: Histologic analysis - Osmosis Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis","og_locale":"en_US","og_type":"article","og_title":"USMLE\u00ae Step 1 Question of the Day: Histologic analysis - Osmosis Blog","og_description":"Prepare for the USMLE Step 1 exam with this detailed question about a 57-year-old woman with malaise and intermittent fevers over the past several weeks.\u00a0Can you correctly identify which of the following findings is most likely to be demonstrated on histologic analysis? A 57-year-old woman presents to her primary care physician with malaise and intermittent [&hellip;]","og_url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis","og_site_name":"Osmosis Blog","article_published_time":"2024-11-06T00:53:00+00:00","article_modified_time":"2025-10-01T19:38:23+00:00","og_image":[{"width":826,"height":823,"url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png","type":"image\/png"}],"author":"Marina Horiates Kerekes, MD &amp; Team","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["Article","BlogPosting"],"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#article","isPartOf":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis"},"author":{"name":"Marina Horiates Kerekes, MD &amp; Team","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc"},"headline":"USMLE\u00ae Step 1 Question of the Day: Histologic analysis","datePublished":"2024-11-06T00:53:00+00:00","dateModified":"2025-10-01T19:38:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis"},"wordCount":769,"commentCount":0,"publisher":{"@id":"https:\/\/www.osmosis.org\/blog\/#organization"},"image":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage"},"thumbnailUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png","articleSection":["Allopathic Medicine (MD)","OMM","Osteopathic Medicine (DO)","Questions of the Day","USMLE Step 1","USMLE\u00ae Step 1"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis","url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis","name":"USMLE\u00ae Step 1 Question of the Day: Histologic analysis - Osmosis Blog","isPartOf":{"@id":"https:\/\/www.osmosis.org\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage"},"image":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage"},"thumbnailUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png","datePublished":"2024-11-06T00:53:00+00:00","dateModified":"2025-10-01T19:38:23+00:00","breadcrumb":{"@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#primaryimage","url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png","contentUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png","width":826,"height":823,"caption":"A study tip titled USMLE Step 1 Question of the Day Histologic Analysis"},{"@type":"BreadcrumbList","@id":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-histologic-analysis#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.osmosis.org\/blog"},{"@type":"ListItem","position":2,"name":"USMLE\u00ae Step 1 Question of the Day: Histologic analysis"}]},{"@type":"WebSite","@id":"https:\/\/www.osmosis.org\/blog\/#website","url":"https:\/\/www.osmosis.org\/blog\/","name":"Osmosis Blog","description":"","publisher":{"@id":"https:\/\/www.osmosis.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.osmosis.org\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.osmosis.org\/blog\/#organization","name":"Osmosis Blog","url":"https:\/\/www.osmosis.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png","contentUrl":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/07\/OsmosisElsevierStacked.png","width":1276,"height":596,"caption":"Osmosis Blog"},"image":{"@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/c7e60a94ecf3ec6e6cfe4855957afafc","name":"Marina Horiates Kerekes, MD &amp; Team","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.osmosis.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c4eaddbf095676223204097f8973e0eed2b2b435a8c32f8f6b8c06da77819aa6?s=96&d=mm&r=g","caption":"Marina Horiates Kerekes, MD &amp; Team"},"description":"Authors: Marina Horiates Kerekes, MD &amp; Osmosis Question Writing Team","url":"https:\/\/www.osmosis.org\/blog\/author\/marinahoriateskerekesandteam"}]}},"jetpack_featured_media_url":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/10\/histologic-analysis-10-24.png","jetpack-related-posts":[{"id":681,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-second-degree-mobitz-type-ii-av-block","url_meta":{"origin":4776,"position":0},"title":"USMLE\u00ae Step 2 CK Question of the Day: Second Degree Mobitz type II AV block","author":"Marina Horiates Kerekes, MD &amp; Team","date":"May 4, 2022","format":false,"excerpt":"Enhance your USMLE\u00ae Step 2 CK exam prep with this clinical case involving a 66-year-old woman with left-sided weakness and symptoms suggestive of cardiac issues. Test your clinical knowledge and improve your diagnostic skills for effective patient care!","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE Step 2 CK Question of the Day Second Degree Mobitz type II AV block","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/31.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/31.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/31.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/31.webp 2x"},"classes":[]},{"id":6140,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-2-ck-question-of-the-day-holosystolic-murmur","url_meta":{"origin":4776,"position":1},"title":"USMLE\u00ae Step 2 CK Question of the Day:\u00a0Holosystolic murmur","author":"Marina Horiates Kerekes, MD &amp; Team","date":"June 25, 2025","format":false,"excerpt":"Explore today\u2019s USMLE\u00ae Step 2 CK question on a case of holosystolic murmur and learn the most likely organism causing it.","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE Step 2 CK Question of the Day\u00a0Holosystolic murmur","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/07\/Step2_QOTD_Q1_HolosystolicMurmur_2025_SM-1.png","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/07\/Step2_QOTD_Q1_HolosystolicMurmur_2025_SM-1.png 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/07\/Step2_QOTD_Q1_HolosystolicMurmur_2025_SM-1.png 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/07\/Step2_QOTD_Q1_HolosystolicMurmur_2025_SM-1.png 2x"},"classes":[]},{"id":1031,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-bacillary-angiomatosis","url_meta":{"origin":4776,"position":2},"title":"USMLE\u00ae Step 1 Question of the Day: Bacillary Angiomatosis","author":"Marina Horiates Kerekes, MD &amp; Team","date":"August 11, 2021","format":false,"excerpt":"Each week, Osmosis shares a USMLE\u00ae Step 1-style practice question to test your knowledge of medical topics. Today's case involves a 30-year-old woman with HIV who has recently developed skin nodules. The woman also works in a pet store. Can you figure it out? A 30-year-old woman with\u00a0HIV\u00a0comes to the\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-bacillary-angiomatosis.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-bacillary-angiomatosis.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-bacillary-angiomatosis.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-bacillary-angiomatosis.webp 2x"},"classes":[]},{"id":4238,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pathogen-test","url_meta":{"origin":4776,"position":3},"title":"USMLE\u00ae Step 1 Question of the Day: Pathogen test","author":"Marina Horiates Kerekes, MD &amp; Team","date":"September 11, 2024","format":false,"excerpt":"Prepare for your USMLE Step 1 exam with this question focused on identifying pathogens in immunocompromised patients. Understand the presentation and diagnostic features of Cryptococcus neoformans and other pathogens in similar settings. A 45-year-old man is brought to the emergency department due to confusion and altered mental status. His friend,\u2026","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-pathogen-test.webp","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-pathogen-test.webp 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-pathogen-test.webp 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2024\/09\/usmle-pathogen-test.webp 2x"},"classes":[]},{"id":5561,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-skin-blistering-2","url_meta":{"origin":4776,"position":4},"title":"USMLE\u00ae Step 1 Question of the Day:\u00a0Skin blistering","author":"Marina Horiates Kerekes, MD &amp; Team","date":"March 6, 2025","format":false,"excerpt":"Get ready for the USMLE\u00ae Step 1 exam with a case study on skin blistering and Stevens-Johnson syndrome. Learn to identify common triggers, including medications like trimethoprim-sulfamethoxazole, and understand the importance of recognizing and addressing this serious condition. Test your clinical knowledge and prepare effectively for Step 1!","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"USMLE\u00ae Step 1 Question of the Day Skin blistering","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/02\/skin_blistering.png","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/02\/skin_blistering.png 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/02\/skin_blistering.png 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/02\/skin_blistering.png 2x"},"classes":[]},{"id":9767,"url":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-chronic-cough","url_meta":{"origin":4776,"position":5},"title":"USMLE\u00ae Step 1 Question of the Day:\u00a0Chronic cough","author":"Rowan Bell, MD","date":"April 1, 2026","format":false,"excerpt":"A histology image reveals a granulomatous lesion with central necrosis. Learn how caseating granulomas develop, how to distinguish infectious etiologies from other causes, and how to integrate histology with clinical context to sharpen differential diagnosis and clinical reasoning.","rel":"","context":"In &quot;Allopathic Medicine (MD)&quot;","block_context":{"text":"Allopathic Medicine (MD)","link":"https:\/\/www.osmosis.org\/blog\/category\/medicine"},"img":{"alt_text":"","src":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/04\/Step-1-question-of-the-day-Chronic_Cough.png","width":350,"height":200,"srcset":"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/04\/Step-1-question-of-the-day-Chronic_Cough.png 1x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/04\/Step-1-question-of-the-day-Chronic_Cough.png 1.5x, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2026\/04\/Step-1-question-of-the-day-Chronic_Cough.png 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/4776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/users\/202"}],"replies":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/comments?post=4776"}],"version-history":[{"count":2,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/4776\/revisions"}],"predecessor-version":[{"id":7177,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/posts\/4776\/revisions\/7177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/media\/4777"}],"wp:attachment":[{"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/media?parent=4776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/categories?post=4776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.osmosis.org\/blog\/wp-json\/wp\/v2\/tags?post=4776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}