{"id":7297,"date":"2025-08-06T00:01:00","date_gmt":"2025-08-06T08:01:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=7297"},"modified":"2026-03-20T13:49:50","modified_gmt":"2026-03-20T21:49:50","slug":"nclex-question-of-the-day-sickle-cell-anemia","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-sickle-cell-anemia","title":{"rendered":"NCLEX-RN\u00ae Question of the Day: Sickle cell anemia"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-sickle-cell-anemia\/#The_correct_answer_to_todays_NCLEX-RN%C2%AE_Question_is%E2%80%A6\" >The correct answer to today&#8217;s NCLEX-RN\u00ae Question is&#8230;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-sickle-cell-anemia\/#Main_Takeaway\" >Main Takeaway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-sickle-cell-anemia\/#Incorrect_Answer_Explanations\" >Incorrect Answer Explanations<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-sickle-cell-anemia\/#Want_to_learn_more_about_this_topic\" >Want to learn more about this topic?<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><strong><em>Today&#8217;s NCLEX-RN\u00ae question of the day focuses on Sickle cell anemia. Do you know the answer? Let&#8217;s find out!<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The nurse in the pediatric emergency department is caring for a child with sickle cell anemia. Based on the clinical findings, which sickle cell crisis is this patient <strong>most<\/strong> likely experiencing?&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Vaso-occlusive crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Sequestration crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Hyperhemolytic crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. Aplastic crisis<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"975\" height=\"966\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/image_caf8e0.png\" alt=\"ELECTRONIC HEALTH RECORD\nName: Willow Barnes\nDOB: 10\/7\/2017 (age 7)\nAllergies: Penicillin\nSex: Female\nAdmission note: Patient brought in by caretaker for dizziness, weakness, and loss of appetite which as progressively worsened over the last week.\n\nVital Signs  \nTemperature (oral) \/ 36-37\u00b0C or 97-99\u00b0F \nHeart Rate 122\/min \nRespirations 24\/min \nBlood Pressure 82\/51 mmHg \nPain: 0 out of 10\n\nMedications: Recently completed course of oseltamivir\n\nLaboratory Results\nRed blood cells 2.8 million\/mm3 \nHemoglobin 8 g\/dL \nHematocrit 25% \" class=\"wp-image-7300\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/image_caf8e0.png 975w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/image_caf8e0.png?resize=150,150 150w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/image_caf8e0.png?resize=300,297 300w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/image_caf8e0.png?resize=768,761 768w\" sizes=\"auto, (max-width: 975px) 100vw, 975px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><em>Scroll down for the correct answer!<\/em><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Nurses Learn by Osmosis.org\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/kGJCkPfFypA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.osmosis.org\/ultimate-guide\/nclex-rn\" target=\"_blank\" rel=\"noreferrer noopener\"><strong><u>Check out our&nbsp;NCLEX-RN Study Plan Guide!<\/u><\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_NCLEX-RN%C2%AE_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s NCLEX-RN\u00ae Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. Aplastic crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> Given this patient\u2019s clinical findings and recent diagnosis of influenza (which can be inferred due to recent treatment with oseltamivir), it is most likely that they are experiencing aplastic crisis. This occurs when the bone marrow temporarily ceases erythropoiesis despite the need for new red blood cells (RBCs). Aplastic crises are typically preceded by a viral infection, like influenza, that shuts down the bone marrow leading to profound anemia and hypoxia manifesting as fatigue, weakness, dizziness, and tachycardia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Takeaway\"><\/span>Main Takeaway<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sickle cell anemia is a genetic condition resulting in red blood cells (RBCs) that are sickle-shaped, inflexible, and easily destroyed. Individuals with sickle cell anemia can have intermittent episodes of extensive sickling, called crises. These crises can be categorized as vaso-occlusive, aplastic, sequestration, and hyperhemolytic. A vaso-occlusive crisis occurs when the sickled RBCs clump together and block vascular blood flow, resulting in inflammation, vasoconstriction, tissue ischemia, and necrosis, which causes intense pain and organ damage. Aplastic crises occur when the bone marrow temporarily ceases erythropoiesis despite the need for new RBCs. Aplastic crises are typically preceded by a viral infection that shuts down the bone marrow leading to profound anemia and hypoxia manifesting as fatigue, weakness, dizziness, and tachycardia. Sequestration crises occur when large numbers of sickled RBCs pool in the spleen. This can lead to a reduced circulating blood volume manifesting as hypovolemia, shock, and even death. Lastly, hyperhemolytic crises occur when there is excessive destruction of RBCs precipitated by certain infections or medications. It manifests with fever and jaundice. Given this patient\u2019s findings and recent influenza treatment with oseltamivir, it is mostly likely they are experiencing aplastic crisis.&nbsp;&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_Answer_Explanations\"><\/span>Incorrect Answer Explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. Vaso-occlusive crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> Given this patient\u2019s clinical findings, it is not likely that they are experiencing vaso-occlusive crisis. A vaso-occlusive crisis occurs when the sickled red blood cells (RBCs) clump together and block vascular blood flow, resulting in inflammation, vasoconstriction, tissue ischemia, and necrosis, which causes intense pain and organ damage.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. Sequestration crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> Given this patient\u2019s clinical findings, it is not likely that they are experiencing sequestration crisis. Sequestration crises occur when large numbers of sickled red blood cells (RBCs) pool in the spleen. This can lead to a reduced circulating blood volume manifesting as hypovolemia, shock, and even death.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Hyperhemolytic crisis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> Given this patient\u2019s clinical findings, it is not likely that they are experiencing hyperhemolytic crisis. Hyperhemolytic crises occur when there is excessive destruction of red blood cells (RBCs) precipitated by certain infections or medications. Although this patient did recently have an infection, this crisis usually manifests with fever and jaundice.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Want_to_learn_more_about_this_topic\"><\/span>Want to learn more about this topic?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Watch the Osmosis video: <a href=\"https:\/\/www.osmosis.org\/learn\/Sickle-cell_disease:_Nursing_Process_(ADPIE)\">Sickle-cell disease: Nursing Process (ADPIE)<\/a><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/osmosis.org\/create\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_RN3_2023.png?w=700\" alt=\"\" class=\"wp-image-5064\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_RN3_2023.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_RN3_2023.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Want more NCLEX\u00ae-style practice questions? Try Osmosis today! Access your&nbsp;<a href=\"https:\/\/www.osmosis.org\/create\" target=\"_blank\" rel=\"noreferrer noopener\">free trial<\/a>&nbsp;and find out why millions of current and future clinicians and caregivers love learning with us.<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Challenge yourself with a case on sickle cell anemia crises. Which crisis matches a child with recent influenza and symptoms of profound anemia and fatigue?<\/p>\n","protected":false},"author":279,"featured_media":7299,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[20,29,1367,1366,32],"tags":[621,1284,1288,1287,244,245,267,1283,1285,1286],"class_list":["post-7297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exam-prep","category-nclex","category-nclex-rn","category-questions","category-nursing","tag-anemia","tag-aplastic-crisis","tag-hemoglobinopathy","tag-hyperhemolytic-crisis","tag-nclex-rn","tag-nursing-education","tag-pediatric-nursing","tag-sequestration-crisis","tag-sickle-cell-anemia","tag-vaso-occlusive-crisis"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCLEX-RN\u00ae Question of the Day: Sickle cell anemia - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-sickle-cell-anemia\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCLEX-RN\u00ae Question of the Day: Sickle cell anemia - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Challenge yourself with a case on sickle cell anemia crises. 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