{"id":7302,"date":"2025-08-13T00:01:00","date_gmt":"2025-08-13T08:01:00","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=7302"},"modified":"2026-03-20T13:49:50","modified_gmt":"2026-03-20T21:49:50","slug":"nclex-question-of-the-day-philadelphia-chromosome","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-philadelphia-chromosome","title":{"rendered":"NCLEX-RN\u00ae Question of the Day: Philadelphia chromosome"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-philadelphia-chromosome\/#The_correct_answer_to_todays_NCLEX-RN%C2%AE_Question_is%E2%80%A6\" >The correct answer to today&#8217;s NCLEX-RN\u00ae Question is&#8230;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-philadelphia-chromosome\/#Main_Takeaway\" >Main Takeaway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-philadelphia-chromosome\/#Incorrect_Answer_Explanations\" >Incorrect Answer Explanations<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-philadelphia-chromosome\/#Want_to_learn_more_about_this_topic\" >Want to learn more about this topic?<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><strong><em>Today&#8217;s NCLEX-RN\u00ae question of the day focuses on the Philadelphia chromosome. Do you know the answer? Let&#8217;s find out!<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The nurse in the family medicine clinic is caring for a child who recently tested positive for the Philadelphia chromosome. Their caregiver asks, \u201cWhat does this mean for my child?\u201d <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Which is the <em>best <\/em>response by the nurse?&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. \u201cYour child has a chromosomal abnormality that increases their risk for developing leukemia.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. \u201cThis means that your child has an increased risk of retinoblastoma, a cancer of the retina.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Your child was likely exposed to Epstein-Barr virus in utero, increasing their risk for lymphoma.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. \u201cThe Philadelphia chromosome makes it more likely your child will develop hepatocellular carcinoma later in life.\u201d<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><em>Scroll down for the correct answer!<\/em><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Nurses Learn by Osmosis.org\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/kGJCkPfFypA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.osmosis.org\/ultimate-guide\/nclex-rn\" target=\"_blank\" rel=\"noreferrer noopener\"><strong><u>Check out our&nbsp;NCLEX-RN Study Plan Guide!<\/u><\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_NCLEX-RN%C2%AE_Question_is%E2%80%A6\"><\/span>The correct answer to today&#8217;s NCLEX-RN\u00ae Question is&#8230;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. \u201cYour child has a chromosomal abnormality that increases their risk for developing leukemia.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> This is the best response by the nurse. Genetic changes such as chromosomal translocations, where pieces of two chromosomes split off and swap places, like with the Philadelphia chromosome, are also associated with an increased risk of leukemia, a cancer of blood-forming tissues that disrupts the normal function of bone marrow.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Takeaway\"><\/span>Main Takeaway<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The cause of childhood cancer is multifactorial, meaning a child\u2019s unique genetic factors and environmental factors interact to promote the development of cancer. Even so, these factors are often not known at the time of diagnosis, so in many cases the exact cause of cancer in children is unknown. Genetic factors involved in cancer can be mutations that are either inherited or acquired. These include mutations that typically occur in genes that regulate cell division, including proto-oncogenes, which promote cell division, or tumor suppressor genes that inhibit uncontrolled cell division. Genetic changes such as chromosomal translocations, where pieces of two chromosomes split off and swap places, like with the Philadelphia chromosome, are also associated with an increased risk of leukemia, a cancer of blood-forming tissues that disrupts the normal function of bone marrow.&nbsp;&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"975\" height=\"770\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/Philadelphia-chromosome-causes-risks.png\" alt=\"CAUSES &amp; RISK FACTORS\nGenetic Factors\n- Increased risk of leukemia\n- Chromosomal translocations\nPhiladelphia chromosome\" class=\"wp-image-7305\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/Philadelphia-chromosome-causes-risks.png 975w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/Philadelphia-chromosome-causes-risks.png?resize=300,237 300w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/08\/Philadelphia-chromosome-causes-risks.png?resize=768,607 768w\" sizes=\"auto, (max-width: 975px) 100vw, 975px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_Answer_Explanations\"><\/span>Incorrect Answer Explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. \u201cThis means that your child has an increased risk of retinoblastoma, a cancer of the retina.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> This is not the best response from the nurse. Mutations in the RB1 tumor suppressor gene are associated with retinoblastoma. Therefore, this does not accurately describe the impact of having the Philadelphia chromosome.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Your child was likely exposed to Epstein-Barr virus in utero, increasing their risk for lymphoma.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> This is not the best response from the nurse. Although strains of the Epstein-Barr virus are associated with Burkitt lymphoma and Hodgkin lymphoma, this does not accurately describe the impact of having the Philadelphia chromosome.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. \u201cThe Philadelphia chromosome makes it more likely your child will develop hepatocellular carcinoma later in life.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rationale:<\/strong> This is not the best response from the nurse. Taking anabolic androgenic steroids increases the risk of hepatocellular carcinoma rather than having the Philadelphia chromosome.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Want_to_learn_more_about_this_topic\"><\/span>Want to learn more about this topic?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Watch the Osmosis video: <a href=\"https:\/\/www.osmosis.org\/answers\/chromosomal-aberrations\">Chromosomal aberrations<\/a><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/osmosis.org\/create\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_RN3_2023.png?w=700\" alt=\"\" class=\"wp-image-5064\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_RN3_2023.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_RN3_2023.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Want more NCLEX\u00ae-style practice questions? Try Osmosis today! Access your&nbsp;<a href=\"https:\/\/www.osmosis.org\/create\" target=\"_blank\" rel=\"noreferrer noopener\">free trial<\/a>&nbsp;and find out why millions of current and future clinicians and caregivers love learning with us.<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Explore a pediatric case involving the Philadelphia chromosome. What does this genetic abnormality mean for leukemia risk in children?<\/p>\n","protected":false},"author":279,"featured_media":7304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[20,29,1367,1366,32],"tags":[1292,1294,1291,1297,1289,244,245,1290,1293,1296,1295],"class_list":["post-7302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exam-prep","category-nclex","category-nclex-rn","category-questions","category-nursing","tag-childhood-cancer","tag-chromosomal-translocation","tag-genetic-mutations","tag-genetics","tag-leukemia","tag-nclex-rn","tag-nursing-education","tag-pediatric-oncology","tag-philadelphia-chromosome","tag-proto-oncogenes","tag-tumor-suppressor-genes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCLEX-RN\u00ae Question of the Day: Philadelphia chromosome - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/nclex-question-of-the-day-philadelphia-chromosome\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCLEX-RN\u00ae Question of the Day: Philadelphia chromosome - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"Explore a pediatric case involving the Philadelphia chromosome. 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