{"id":8917,"date":"2025-12-08T00:01:48","date_gmt":"2025-12-08T08:01:48","guid":{"rendered":"https:\/\/www.osmosis.org\/blog\/?p=8917"},"modified":"2025-12-04T15:56:20","modified_gmt":"2025-12-04T23:56:20","slug":"usmle-step-1-question-of-the-day-pancreatic-enzyme","status":"publish","type":"post","link":"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme","title":{"rendered":"USMLE\u00ae Step 1 Question of the Day:\u00a0Pancreatic enzyme"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">In This Article<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\/#The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\" >The correct answer to today\u2019s USMLE\u00ae Step 1 Question is\u2026<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\/#Incorrect_Answer_Explanations\" >Incorrect Answer Explanations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\/#Main_Explanation\" >Main Explanation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\/#Major_Takeaway\" >Major Takeaway&nbsp;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\/#Want_to_learn_more_about_this_topic\" >Want to learn more about this topic?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\"><em>Today\u2019s USMLE\u00ae Step 1 question of the day focuses on a <strong>young adult diagnosed with maturity onset diabetes of the young (MODY) type 2<\/strong>. Which of the following best describes a <strong>key feature of this enzyme<\/strong>? Let\u2019s find out!<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Maturity onset diabetes of the young (MODY) type 2<\/strong> is a consequence of a <strong>defective pancreatic enzyme<\/strong>, which normally acts as a <strong>glucose sensor<\/strong>, resulting in a <strong>mild hyperglycemia<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Which of the following is a <strong>characteristic of this pancreatic enzyme<\/strong>?&nbsp;<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. It is inhibited by insulin secretion<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. It is found in most tissues of the body<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. It has higher affinity for glucose<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. It converts glucose to glucose-6-phosphate<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. It is stimulated by increased fructose-6-phosphate<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><em>Scroll down for the correct answer!<\/em><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Osmosis.org at the University College London, UK\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/DIp3u0oTLo4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_correct_answer_to_todays_USMLE%C2%AE_Step_1_Question_is%E2%80%A6\"><\/span>The correct answer to today\u2019s USMLE\u00ae Step 1 Question is\u2026<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>D. It converts glucose to glucose-6-phosphate<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Correct: See Main Explanation.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Incorrect_Answer_Explanations\"><\/span>Incorrect Answer Explanations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A. It is inhibited by insulin secretion<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong> <strong>Glucokinase<\/strong>, the <strong>defective enzyme<\/strong> seen in <strong>MODY type 2<\/strong>, is <strong>stimulated by insulin secretion.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B. It is found in most tissues of the body<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong> <strong>Glucokinase<\/strong> is only found in <strong>pancreatic beta cells and liver<\/strong>. In contrast, <strong>hexokinase<\/strong> is found in <strong>most tissues of the body<\/strong>, except pancreatic beta cells and liver.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. It has higher affinity for glucose<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong> <strong>Glucokinase has a lower glucose affinity (higher Km)<\/strong> than other hexokinases, which allows it to <strong>limit the rate of glucose entry<\/strong> into the glycolytic pathway based on <strong>blood glucose levels<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E. It is stimulated by increased fructose-6-phosphate<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Incorrect:<\/strong> <strong>Glucokinase is inhibited by increased fructose-6-phosphate<\/strong> via <strong>negative feedback inhibition.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_Explanation\"><\/span>Main Explanation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Glucokinase and hexokinase<\/strong> are enzymes which <strong>phosphorylate glucose to glucose-6-phosphate<\/strong>, <strong>trapping glucose inside the cell.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Glucokinase<\/strong> is present in <strong>hepatocytes of the liver and beta cells of pancreas.<\/strong> Compared to hexokinase, glucokinase has a <strong>higher Km (lower binding affinity)<\/strong> and a <strong>higher Vmax (increased capacity)<\/strong>. <strong>Glucokinase is induced by insulin<\/strong> and undergoes <strong>negative feedback inhibition by fructose-6-phosphate.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hexokinase<\/strong> is found in <strong>most tissues<\/strong>. Compared to glucokinase, hexokinase has a <strong>lower Km (higher binding affinity)<\/strong> and <strong>lower Vmax (lower capacity)<\/strong>. Notably, the enzyme is <strong>not induced by insulin<\/strong> but does undergo <strong>negative feedback inhibition by glucose-6-phosphate.<\/strong>&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"975\" height=\"513\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/12\/image_b8dc32.png\" alt=\"Comparison table between Hexokinase and Glucokinase.\n\n* **Location:** Hexokinase is found in most tissues except liver and pancreatic beta cells; Glucokinase is found in the liver and pancreatic beta cells.\n* **Induced by insulin:** Hexokinase is not induced by insulin; Glucokinase is induced by insulin.\n* **Cause of feedback inhibition:** Hexokinase is inhibited by glucose-6-phosphate; Glucokinase is inhibited by fructose-6-phosphate.\n* **Affinity for glucose:** Hexokinase has high affinity and is active at low glucose concentrations; Glucokinase has low affinity and is active at high glucose concentrations.\" class=\"wp-image-8922\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/12\/image_b8dc32.png 975w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/12\/image_b8dc32.png?resize=300,158 300w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/12\/image_b8dc32.png?resize=768,404 768w\" sizes=\"auto, (max-width: 975px) 100vw, 975px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Major_Takeaway\"><\/span>Major Takeaway&nbsp;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Glucokinase (liver, \u03b2 cells of pancreas)<\/strong> and <strong>hexokinase (other body tissues)<\/strong> are enzymes which <strong>phosphorylate glucose to glucose-6-phosphate<\/strong>, <strong>trapping glucose inside the cell.<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Want_to_learn_more_about_this_topic\"><\/span>Want to learn more about this topic?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Watch this Osmosis video:<\/strong> <a href=\"https:\/\/www.osmosis.org\/learn\/Glycolysis\"><strong>Glycolysis<\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span>References<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bender D.A., &amp; Mayes P.A. (2018). Glycolysis &amp; the oxidation of pyruvate. Rodwell V.W., &amp; Bender D.A., &amp; Botham K.M., &amp; Kennelly P.J., &amp; Weil P(Eds.), Harper&#8217;s Illustrated Biochemistry, 31e. McGraw-Hill.&nbsp;<\/li>\n\n\n\n<li>Robblee, J. and Katzberg, H. (12 July 2016). Distinguishing Radiculopathies from Mononeuropathies. Frontiers in Neurology 7(111): 1-5.&nbsp;<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.osmosis.org\/plans\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_GENERAL3_2023.png?w=700\" alt=\"\" class=\"wp-image-5048\" srcset=\"https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_GENERAL3_2023.png 700w, https:\/\/www.osmosis.org\/blog\/wp-content\/uploads\/sites\/2\/2025\/01\/Blog_Display_Ads_GENERAL3_2023.png?resize=300,107 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Want more <strong>USMLE\u00ae Step 1<\/strong> practice questions? Try <strong>Osmosis from Elsevier<\/strong> today! Access your&nbsp;<em><a href=\"https:\/\/www.osmosis.org\/plans\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>free trial<\/strong><\/a><\/em>&nbsp;and discover why millions of current and future <strong>clinicians <\/strong>and <strong>caregivers <\/strong>love <strong>learning with us<\/strong>.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>MODY type 2 arises from a defect in a pancreatic enzyme crucial for glucose sensing. Discover the distinctive characteristics that set this enzyme apart in glucose metabolism.<\/p>\n","protected":false},"author":204,"featured_media":8993,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[27,20,16,1366,1369,44],"tags":[2329,2324,2334,2323,2322,2325,2328,2326,2330,2333,81,2332,2331,2321,2327],"class_list":["post-8917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-exam-prep","category-do","category-questions","category-step-1-questions","category-step-1","tag-beta-cells","tag-diabetes-genetics","tag-diabetes-pathophysiology","tag-enzyme-regulation","tag-glucokinase","tag-glucose-metabolism","tag-glucose-phosphorylation","tag-glucose-6-phosphate","tag-glycolysis","tag-hexokinase","tag-insulin","tag-maturity-onset-diabetes","tag-metabolic-enzymes","tag-mody-type-2","tag-pancreatic-enzyme"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>USMLE\u00ae Step 1 Question of the Day:\u00a0Pancreatic enzyme - Osmosis Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.osmosis.org\/blog\/usmle-step-1-question-of-the-day-pancreatic-enzyme\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USMLE\u00ae Step 1 Question of the Day:\u00a0Pancreatic enzyme - Osmosis Blog\" \/>\n<meta property=\"og:description\" content=\"MODY type 2 arises from a defect in a pancreatic enzyme crucial for glucose sensing. 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