Approach to benzodiazepine and barbiturate use, intoxication, and overdose Quiz: Ace Your Exams
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A 50-year-old man is brought to the emergency department for a 30-minute history of sedation and unresponsiveness. The patient was found by his significant other on the floor of their apartment next to an empty bottle of lorazepam. According to the fiancé, the patient had recently lost a job and may have increased the dose of lorazepam without informing a physician, due to worsening anxiety. Past medical history includes generalized anxiety disorder and generalized epilepsy. Temperature is 37.0°C (98.6°F), pulse is 50/min, respirations are 10/min, and blood pressure is 115/65 mmHg. Cardiopulmonary examination shows slowed breathing. Mental status exam reveals a heavily sedated individual who does not respond to verbal stimuli. Naloxone is administered without improvement in sedation. Glasgow coma scale (GCS) score is 10. Which of the following is the most appropriate next step in management?
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