Approach to myeloproliferative neoplasms Quiz: Ace Your Exams
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A 67-year-old woman presents to the hematology clinic with complaints of progressive fatigue, early satiety, and discomfort in the left upper abdomen. She has been experiencing night sweats and unexplained weight loss over the last few months. Her past medical history is significant for coronary artery disease, hypertension, and type 2 diabetes mellitus which are all well controlled with medications. Vital signs are within normal limits. There is marked splenomegaly on abdominal examination. Laboratory results are shown below. An attempt to perform a bone marrow biopsy results in the inability to aspirate bone marrow fluid despite several attempts. Which of the following is most likely to be seen on this patient’s peripheral blood smear?
| Laboratory value | Result |
| Serum chemistries | |
| Hemoglobin | 9.1 g/dL |
| Hematocrit | 27 % |
| Leukocyte count | 3,100 /mm3 |
| Platelet count | 105,000 /mm3 |
| JAK2 mutation | Positive |
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