Benign prostatic hypertrophy and prostate cancer Quiz: Ace Your Exams
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A 70-year-old man presents to the clinic with a six-month history of worsening urinary frequency, nocturia, difficulty initiating urination, and a weak urinary stream. He reports occasional dribbling at the end of urination. He has no hematuria, dysuria, unintentional weight loss, bone pain, or recent illnesses. Past medical history includes hypertension and type 2 diabetes, both well-controlled. He has no family history of prostate cancer. On physical examination, the abdomen is soft, non-distended, and non-tender. A digital rectal examination (DRE) reveals a nontender symmetrically enlarged prostate with a firm palpable nodule in the right lobe. Neurologic examination is within normal limits. Using the urinary symptom score/International Prostate Symptom Score (IPSS), the patient has a 10. Laboratory tests show a prostate-specific antigen (PSA) level of 10.2 ng/mL (normal <4 ng/mL). Urinalysis is negative for signs of infection and hematuria. What is the best next step in management?
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