Cystic fibrosis Quiz: Ace Your Exams
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A scientist is researching the effect of a new drug, Drug X, on protein processing in cells with a mutation in a particular gene encoding a transmembrane ion channel. The scientist notices that the mutated gene creates an unstable and misfolded protein that accumulates in the endoplasmic reticulum. The mutated protein is eventually transported to the cytosol, where it is ubiquitinated and degraded by proteasomes. Addition of Drug X improves the conformational stability of the protein, resulting in increased processing and trafficking of mature protein to the cell surface. Drug X is most similar to which of the following medications?
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