Diabetes insipidus Quiz: Ace Your Exams
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A 21-year-old woman presents to the clinic because of increased thirst and urination. Her symptoms started gradually around 2 months ago. Past medical history is notable for cystic acne. She was started on demeclocycline in the last appointment 3 months ago. Review of systems is otherwise unremarkable. Vitals are within normal limits. Physical examination shows facial acne that has improved from the last visit. Laboratory studies are as follows:
The patient is provided hydrochlorathiazide for treatment of her condition, instructed to discontinue demeclocycline, and encouraged to follow a low-sodium, low-protein diet. Which of the following best describes the rationale for treatment with hydrochlorathiazide?
| Laboratory value | Result | Reference Range |
| Serum osmolality | 300 mOsm/kg | 275-295 mOsm/kg |
| Urine osmolality | 195 mOsm/kg | 50-1,400 mOsm/kg |
| 2 hours after a trial of synthetic ADH administration | ||
| Serum osmolality | 305 mOsm/kg | 275-295 mOsm/kg |
| Urine osmolality | 201 mOsm/kg | 50-1,400 mOsm/kg |
The patient is provided hydrochlorathiazide for treatment of her condition, instructed to discontinue demeclocycline, and encouraged to follow a low-sodium, low-protein diet. Which of the following best describes the rationale for treatment with hydrochlorathiazide?
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