Diabetes mellitus (pediatrics) Quiz: Ace Your Exams
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A 10-year-old boy is brought to the clinic for polydipsia and polyuria for 3 months. His parent reports that he plays basketball at school but seems to remain excessively thirsty even when not playing sports. The patient has no vomiting, diarrhea, edema, or headaches. Past medical and surgical history are non-contributory. Family history is positive for diabetes mellitus in many family members. The patient’s parent is being treated for DM type 2 that she developed in her early 30’s. Temperature is 37.0°C (98.6°F), pulse is 77/min, respirations are 19/min, and blood pressure is 115/76 mm Hg. Body mass index (BMI) is at the 67th percentile. Mucous membranes are moist, and skin turgor is normal. Cardiopulmonary and abdominal examinations are unremarkable. Labs are shown below. Which of the following is the most likely diagnosis?
| Laboratory value | Result |
| Hemoglobin A1c (HbA1c) | 7% |
| Fasting blood glucose | 140 mg/dL |
| C-peptide | 1.26 nmol/L (reference range; 0.26 – 1.27 nmol/L) |
| Islet antibodies | Negative |
| Gene mutation | Hepatocyte nuclear factor 1-alpha |
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