Nephrotic syndromes Quiz: Ace Your Exams

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A 62-year-old woman comes to the clinic due to progressive fatigue, weight loss, and ankle swelling for the past two months. Physical examination shows 2+ pitting edema around the ankles. Cardiovascular and respiratory examinations are non-contributory. Laboratory results show a serum creatinine level of 3.1 mg/dL, albumin of 2.2 g/dL, and total cholesterol concentration of 290 mg/dL. Urinalysis results show 3+ proteinuria without hematuria or red cell casts. Renal biopsy is performed, and the results are shown below:  

A close-up view of a kidney glomerulus tissue section, stained purple, showing intricate structures w/ a thickened basement membrane.
Reproduced from: Wikipedia    

Which of the following is the most likely explanation for this patient’s condition?  

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