Infertility Quiz: Ace Your Exams

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A 27-year-old nulligravid woman presents for an infertility evaluation. She and her male partner have been trying to conceive for 12 months without success, despite regular intercourse two to three times per week. Her menstrual cycles are irregular, coming once every 25 to 40 days. She has no dysmenorrhea. She has cystic acne that has worsened since stopping her combined oral contraceptive pills last year. She has a history of prediabetes mellitus and a single episode of chlamydia 5 years ago. She has no history of intraabdominal surgeries. Vital signs are normal except for a blood pressure of 138/86 mm Hg and body mass index of 31 kg/m2. Physical exam shows dark hair growth around the nipples and on the upper back, and pelvic exam is notable for bilateral fullness in the adnexa. Her male partner has not fathered any children previously and has no significant past medical history and no history of genital infections or trauma. Surgical history is significant for successful inguinal hernia repair. Laboratory findings are detailed in the table below. Which of the following is the most likely cause of infertility in this couple? 

 Test     Result     Reference Range    
Cycle day 3 (CD3) serum chemistries
Follicle-stimulating hormone (FSH) mIU/mL < 10 mIU/mL
Luteinizing hormone (LH)  mIU/mL     < 10 mIU/mL    
Estradiol (E2)     50 pg/mL     < 80 pg/mL    
Total testosterone (TT)     65     < 60 ng/dL    
Thyroid-stimulating hormone (TSH)     2.0     0.5 to 4.5 mIU/L    
Prolactin (PRL)     12 ng/mL     < 20 ng/mL    
Cycle day 21 (CD21) serum chemistries     
Progesterone     3 ng/mL     > 5 ng/mL    
Imaging
Hysterosalpingogram (HSG)Bilateral fill and spill of dye    No intracavitary filling defectsBilateral fill and spill of dye    No intracavitary filling defects
Semen analysis    
Sperm concentration     17 million/mL      ≥ 15 million/mL    
Total motility     42%     ≥ 40%    
Morphology     8% normal forms     ≥ 4% normal forms    

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