Papulosquamous and inflammatory skin disorders Quiz: Ace Your Exams

Get ready to dominate your medical and nursing exams by using our dynamic quizzes to elevate your knowledge and increase your confidence. Whether you're gearing up for the USMLE®, COMLEX®, or your next in-class assessment, Osmosis quizzes tackle key topics in pathology, diagnostics, and treatment approaches. By honing in on clinical readiness and decision-making, we make sure the knowledge you gain empowers you both in the classroom and in real-world practice. Jump in and supercharge your exam prep!

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A 40-year-old woman presents to the office because of shortness of breath and nonproductive cough for the past two months. She reports that she often has to stop to catch her breath after climbing a flight of stairs to her apartment complex. She has seasonal allergies, for which she takes over-the-counter medications. Review of systems reveals occasional joint pain in the ankles and knees and painful swellings on the shins. The remainder of the history is noncontributory. Temperature is 37.2°C (99.0°F), pulse is 80/min, respirations are 20/min, and blood pressure is 125/80 mmHg. Physical examination shows mild tenderness of the knees and ankles and tender, immobile, erythematous nodules on the shins bilaterally. Chest x-ray shows bilateral hilar lymphadenopathy. CT-guided transbronchial biopsy is shown:

A high magnification light micrograph shows a granuloma with numerous histiocytes in the center, surrounded by a ring of smaller lymphocytes.
Reproduced from Flickr

Which of the following is the most likely underlying cause of this patient’s dermatologic lesions on the shins?

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Choose an option: