Thrombosis syndromes (hypercoagulability) Quiz: Ace Your Exams

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A scientist is investigating different types of mutations and their associated thrombophilias. The scientist identifies a single point mutation in the terminal nucleotide of the 3’ untranslated region of a specific gene, which corresponds to the messenger RNA (mRNA) sequence responsible for polyadenylation. A patient with this mutation will most likely have which of the following findings?

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Arterial thrombosis; elevated prothrombin levels

Venous thromboembolism; activated protein C resistance

Hemarthroses; low levels of factor VIII

Easy bruising; low levels of factor IX

Deep vein thrombosis; No change in PTT following heparin administration