Tuberculosis (extrapulmonary and latent) Quiz: Ace Your Exams
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A 43-year-old man presents to the infectious disease clinic for initiation of treatment for extrapulmonary tuberculosis. The patient currently lives in a shelter and has a history of intravenous substance use disorder. He was recently hospitalized for sepsis and was found to have spinal tuberculosis. Chest imaging at that time showed no pulmonary tuberculosis. The patient declined treatment during the hospital stay and signed out against medical advice. The patient was subsequently contacted by the local health department and told to report to an infectious disease clinic. Temperature is 37.5 ºC (99.5 ºF), pulse is 96/min, blood pressure is 122/77 mmHg, respiratory rate is 16/min, and oxygen saturation is 98% on room air. Physical examination is unremarkable, other than mild point tenderness along several spinous processes in the upper lumbar spine. Drug susceptibility testing that was performed on the tuberculosis isolates obtained during hospitalization found resistance to isoniazid. Which of the following medication regimens is most appropriate at this time?
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