ACE inhibitors, ARBs and direct renin inhibitors are all medications used to treat high blood pressure. ACE or angiotensin-converting enzyme inhibitors work by blocking the enzyme that converts angiotensin I to angiotensin II. This prevents the body from producing too much of the hormone, which can lead to hypertension. ARBs or angiotensin II receptor blockers work by blocking the receptors that angiotensin II binds to constrict blood vessels. This relaxes the blood vessels and lowers blood pressure. Direct renin inhibitors work by inhibiting renin, the enzyme that converts angiotensinogen to angiotensin I, which also reduces blood pressure. All three of these medications can be used alone or in combination with other medications to safely lower blood pressure.
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