79,633views
00:00 / 00:00
Physiology
Cardiovascular system anatomy and physiology
Lymphatic system anatomy and physiology
Coronary circulation
Blood pressure, blood flow, and resistance
Pressures in the cardiovascular system
Laminar flow and Reynolds number
Resistance to blood flow
Compliance of blood vessels
Control of blood flow circulation
Microcirculation and Starling forces
Measuring cardiac output (Fick principle)
Stroke volume, ejection fraction, and cardiac output
Cardiac contractility
Frank-Starling relationship
Cardiac preload
Cardiac afterload
Law of Laplace
Cardiac and vascular function curves
Altering cardiac and vascular function curves
Cardiac work
Cardiac cycle
Pressure-volume loops
Changes in pressure-volume loops
Physiological changes during exercise
Cardiovascular changes during hemorrhage
Cardiovascular changes during postural change
Normal heart sounds
Abnormal heart sounds
Action potentials in myocytes
Action potentials in pacemaker cells
Excitability and refractory periods
Cardiac excitation-contraction coupling
Electrical conduction in the heart
Cardiac conduction velocity
ECG basics
ECG normal sinus rhythm
ECG intervals
ECG QRS transition
ECG axis
ECG rate and rhythm
ECG cardiac infarction and ischemia
ECG cardiac hypertrophy and enlargement
Baroreceptors
Chemoreceptors
Renin-angiotensin-aldosterone system
Abnormal heart sounds
0 / 14 complete
0 / 5 complete
of complete
of complete
2022
2021
2020
2019
2018
2017
2016
diastolic murmur in p. 297
heart murmurs with p. 298
heart murmur with p. 298
heart murmurs p. 298
systolic murmur in p. 297
diastolic murmur in p. 297
heart murmur with p. 298
heart murmur p. 298
heart murmurs of p. 298, 298
heart murmur with p. 298
heart murmurs p. 298
aortic regurgitation p. 716
aortic stenosis p. 716
auscultation of p. 297
cardiomyopathies p. 317
patent ductus arteriosus p. 305
systolic murmur in p. 297
heart murmurs in p. 298
heart murmur with p. 298
murmurs caused by p. 297, 298
murmurs caused by p. 297, 298
heart murmur with p. 298
heart murmur with p. 298
murmur in prematurity p. 298
systolic ejection murmur in p. 297
heart murmur with p. 298
heart murmur with p. 298
heart murmurs of p. 298, 298
heart murmurs with p. 298
pansystolic murmur in p. 297
heart murmurs p. 298
pansystolic murmur in p. 297
Antonia Syrnioti, MD
Sam Gillespie, BSc
Marisa Pedron
Tanner Marshall, MS
Justin Ling, MD, MSIf you put a stethoscope over the chest, you’ll usually hear something that sounds like lub dub, lub dub, lub dub, which repeats over and over again, with each cardiac cycle, or heartbeat.
In total, our heart has four valves- two atrioventricular valves, between the atria and the ventricles, which are the tricuspid valve, on the Left side, and the mitral valve, on the left side, and two semilunar valves, between the ventricles and the large arteries coming off of them, which are the pulmonary valve, on the right side, and the aortic valve, on the left side. Normally, in every heartbeat, some valves open, allowing blood to pass through and others close to hold blood within a chamber. The sound of the closing of each of these valves is projected onto the chest wall. The two normal heart sounds are S1, which is basically the tricuspid and mitral valve closing, and S2 which is the aortic and pulmonic valve closing. Between S1 and S2, we have systole, which is when ventricles are contracting and pushing blood out, and between S2 and S1 of the next heart cycle, we have diastole which is when blood is filling the relaxed ventricles. Together, S1 and S2 form the “lub dub” of the heart beat.
Alright, now in addition to S1 and S2, there are two other "extra" sounds that are sometimes heard in the cardiac cycle, called S3 and S4. S3 and S4 are heard in different parts of diastole. In early diastole, which is right after S2, the atrioventricular valves are open and blood is flowing from the atria into the ventricles. If there’s a lot of blood coming in, the ventricles fill up quickly, and fluid waves bounce off of the walls of the ventricles which makes them vibrate, creating a third heart sound, or S3. S3 sounds kind of like “lub-dub-ta”. In trained athletes and also in pregnancy this is totally normal and just means that the ventricles are handling extra blood volume. But an S3 can also be a sign of volume overload, like in congestive heart failure, where there’s too much volume coming into the ventricles. Now, at the end of diastole, just before S1, the atria are contracting to get that last bit of blood into the ventricles. If the ventricles are stiff, meaning that they can’t easily relax, the atria will have to contract extra hard to push that blood in, creating the fourth heart sound, or S4. So, S4 sounds kind of like "ta-lub-dub". Oftentimes, this stiffness is because the ventricular muscles have hypertrophied, or increased in size, in order to pump against high blood pressure in the aorta or pulmonary artery. In other words, S4 is typically a sign of pressure overload, or severe hypertension.
Copyright © 2023 Elsevier, except certain content provided by third parties
Cookies are used by this site.
USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.