Acute disseminated encephalomyelitis

In acute disseminated encephalomyelitis or ADEM, acute means that the disease evolves rapidly, disseminated refers to the fact that there are multiple sites involved, encephalo- refers to the brain, myelo- refers to the spinal cord, and -itis refers to inflammation.

So acute disseminated encephalomyelitis is an autoimmune disease of the central nervous system, where there’s sudden inflammation and demyelination at multiple sites of the brain and spinal cord.

The central nervous system consists of the brain and the spinal cord.

Grossly, the central nervous system can be divided into two main areas: the grey matter, which is made up of neuron cell bodies, and the white matter, which is made up of projections from the neuron cell bodies known as axons and dendrites.

The dendrites receive electrical impulses from other neurons; the neuron cell body has all of the neuron’s main organelles like the nucleus; and finally the axons transmit electrical impulses to the dendrites of the next neuron in the series.

Some axons are surrounded by a fatty protective sheath called myelin that helps increase the speed at which electrical impulses are sent.

This myelin is produced by oligodendrocytes, which are a group of cells that support neurons.

Now, the brain is protected by harmful things in the blood by the blood brain barrier, which only lets certain molecules and cells through. For immune cells like T and B cells that means having the right ligand or surface molecule to get through the blood brain barrier, this is kind of like having a VIP pass to get into an exclusive club.

Once a T cell makes its way in, it can get activated by something it encounters.

Once the T-cell gets activated, it changes the blood brain barrier cells to express more receptors, and this allows immune cells to more easily bind and get in, kind of like bribing the bouncer to let a lot of people in.

In the case of acute disseminated encephalomyelitis, T-cells are activated by myelin.