00:00 / 00:00
0 / 23 complete
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|Complete blood count|
|Prothrombin time (PT)||25 sec|
|Activated partial thromboplastin time (aPTT)||50 sec|
|Bleeding time (BT)||11 minutes|
|Plasma fibrinogen||150 mg/dL (N = 200-400 mg/dL)|
|D-dimer||1200 ng/dL (N = <500 ng/mL)|
Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL), Hairy Cell Leukemia & Adult T-cell Leukemia
associations with p. 730
methotrexate for p. 446
oncogenes and p. 222
acute lymphoblastic leukemia p. 440
With acute leukemia, leuk- refers to white blood cells, and -emia refers to the blood, so in acute leukemia, there’s uncontrolled proliferation of partially developed white blood cells, also called blast cells, which build up in the blood over a short period of time.
AML is more common in old age, where as ALL is more common in children. In both cases, accumulation of blast cells interferes with the development and function of healthy white blood cells, platelets, and red blood cells.
Now, every blood cell starts its life in the bone marrow as a hematopoietic stem cell. Hematopoietic stem cells are multipotent -- meaning that they can give rise to both myeloblasts, which are precursors of myeloid blood cells, and lymphoblasts, which are precursors of lymphoid blood cells.
If a hematopoietic stem cell develops into a myeloid cell, it’ll mature into an erythrocyte -- or a red blood cell, a thrombocyte -- or a platelet, or a leukocyte -- or a white blood cell, like a monocyte or granulocyte.
If a hematopoietic stem cell develops into a lymphoid cell, on the other hand, it’ll mature into some other kind of leukocyte: a T cell, a B cell, or a natural killer cell, which are referred to as lymphocytes.
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