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Acute tubular necrosis

Summary of Acute tubular necrosis
Acute tubular necrosis, one of the most common causes of acute kidney injury, is a medical condition involving the death of tubular epithelial cells which form the renal tubules of the kidneys. Common causes include ischemia and nephrotoxic drugs. The presence of granular, "muddy brown casts" of epithelial cells found in the urine during urinalysis is pathognomonic.. Management relies on aggressive treatment of the precipitating factors (e.g. hydration and cessation of the offending drug). Because tubular cells continually replace themselves, prognosis is good if the cause is corrected, and recovery is likely within 7 to 21 days.



Renal system


Renal and ureteral disorders
Bladder and urethral disorders
Renal system pathology review

Acute tubular necrosis


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High Yield Notes
10 pages

Acute tubular necrosis

17 flashcards

USMLE® Step 1 style questions USMLE

4 questions

USMLE® Step 2 style questions USMLE

3 questions

A 14-year-old girl comes to the emergency department because of worsening fatigue, nausea and vomiting for the past day. For the past week she has been receiving outpatient treatment of intravenous gentamicin for an infectious exacerbation of her longstanding bronchiectasis. She has type 1 diabetes and self-manages her insulin administration. She is afebrile, pulse is 92/min, respirations are 16/min, saturation is 96% on room air, and blood pressure is 142/86. An arterial blood gas shows pH 7.1, PaCO2 22 mmHg, PaO2 85 mmHg, and HCO3 14 mEq/L. Further blood results show an elevated serum blood urea nitrogen (BUN), creatinine and urea. Which of the following is the most likely diagnosis?

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