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Alpha-thalassemia

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High Yield Notes

6 pages

Flashcards

Alpha-thalassemia

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Questions

USMLE® Step 1 style questions USMLE

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A 29-year-old Chinese primigravid woman comes to the clinic at 24 weeks gestation for the first time due to decreased fetal movements. Her prenatal care has been inconsistent, but she has been taking vitamins daily. The patient’s past medical history is significant for anemia. An ultrasound is performed and shows increased placental thickness. The ultrasound also reveals fetal ascites as well as pericardial and pleural effusions. The amniotic fluid index is measured to be 26 cm. Which of the following most accurately describes the predominant form of hemoglobin found in this fetus?  

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Summary

Alpha-thalassemia is an inherited blood disorder in which there is insufficient production of alpha globin chains of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen from the lungs to all parts of the body. Symptoms will vary depending on the extent of the deficiency of the globin chains. Some people with alpha-thalassemia do not have symptoms, while others experience mild to moderate anemia.

Sources

  1. "Robbins and Cotran Pathologic Basis of Disease, Professional Edition E-Book" Elsevier Health Sciences (2014)
  2. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  3. "Alpha and beta thalassemia" PubMed (2009)
  4. "Alpha Thalassemia" NCBI (2021)
  5. "The α-Thalassemias" New England Journal of Medicine (2014)
  6. "Alpha thalassemia" MedlinePlus (2017)

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