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Amyotrophic lateral sclerosis

Summary of Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of the corticospinal tract that involves the death of neurons. ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. This results in difficulty speaking, swallowing, and eventually breathing. Most cases are sporadic however there can be a gene mutation in zinc-copper superoxide dismutase (SODl) which leads to free radical damage to neurons. 

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Pathology

Nervous system

Central nervous system disorders
Central and peripheral nervous system disorders
Peripheral nervous system disorders
Autonomic nervous system disorders
Nervous system pathology review