00:00 / 00:00
0 / 12 complete
0 / 3 complete
HLA-B25 and p. 98
labs/findings p. 722
therapeutic antibodies for p. 120
TNF- αinhibitors for p. 501
So ankylosing spondylitis is a chronic inflammatory disease that affects the vertebral joints and makes the spine really stiff, but can also cause inflammation in other parts of the body like the eyes and blood vessels.
Ankylosing spondylitis, also called Bechterew disease, is part of a group of diseases called seronegative spondyloarthropathies.
Spondyloarthropathies are all autoimmune diseases that affect the joints, and they’re seronegative, which refers to the fact that rheumatoid factor, which is an autoantibody, is not found in the blood.
Alright, so in the healthy adult, the vertebral column is made up of 33 bones.
There are two types of joints between the vertebra.
Between each of the vertebral bodies is an intervertebral disc which is made of type I and type II collagen and has two parts, the annulus fibrosis, an outer fibrous ring, and the nucleus pulposus, an inner jelly-like substance.
Ankylosing spondylitis (AS) is a form of arthritis that primarily affects the spine. This chronic condition can lead to fusion of the vertebrae, resulting in a rigid spine. AS can also affect the sacroiliac joints, peripheral joints, and digits, and in severe cases, it can lead to disability. Some of the symptoms seen in AS include back pain, postural abnormalities, buttock pain, and pain in the peripheral joints such as the hips, knees, and ankles.
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