00:00 / 00:00
|ANTIDEPRESSANTS: TCAs, MAOIs|
Tertiary TCAs: amitriptyline (Elavil), imipramine, clomipramine (Anafranil)
Secondary TCAs: desipramine (Norpramin), nortriptyline (Pamelor)
selegiline (Emsam, Zelapar)
|CLASS||Tricyclic antidepressants (TCAs)||Monoamine oxidase inhibitors (MAOIs)|
|MECHANISM OF ACTION||Inhibition of serotonin and norepinephrine reuptake into nerve endings||Monoamine oxidase inhibition to prevent the breakdown of serotonin, norepinephrine, and dopamine|
|ROUTE(S) OF ADMINISTRATION|
|CONTRAINDICATIONS AND CAUTIONS|
|NURSING CONSIDERATIONS: ANTIDEPRESSANTS (TCAs, MAOIs)|
|ASSESSMENT AND MONITORING||All antidepressants|
|CLIENT EDUCATION||All antidepressants|
Even though the exact cause of major depressive disorder is still unknown, there's some evidence that suggests that it’s related to low levels of neurotransmitters called monoamines, which include serotonin, norepinephrine, and dopamine.
First, let’s focus on tricyclic antidepressants or TCAs for short, which can be further subdivided into tertiary or non-selective TCAs, like amitriptyline, imipramine, and clomipramine; and secondary or selective TCAs, such as desipramine and nortriptyline.
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