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Aphthous ulcers



Gastrointestinal system


Peritoneum and peritoneal cavity
Upper gastrointestinal tract disorders
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Gastrointestinal system pathology review

Aphthous ulcers


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High Yield Notes
11 pages

Aphthous ulcers

4 flashcards
External References

Content Reviewers:

Rishi Desai, MD, MPH


Aphthous ulcers, often called canker sores, are painful inflammatory lesions or spots on the inside of the mouth.

Most often, people develop minor aphthous ulcers, which is where the lesions are a few millimeters across, round or oval in shape, and disappear within a week.

There are also two other unusual variations, however, major aphthous ulcers and herpetiform ulcers, which are much more severe and debilitating.

The underlying cause of this inflammatory disease is not well understood. One theory suggests tissue specific autoimmunity, where a localized cell-mediated immune reaction happens in the oral mucosa creating an accumulation of T-cells, specifically T helper cells Th1 cells, and macrophages, as well as chemokines like interferon-gamma and tumor necrosis factor.

Aphthous ulcers typically arise, either singly, or a few at a time, on the inside of the lips and cheeks or under the tongue.

Initially there is a small raised bump of inflammation in your mouth, and as it heals it turns into an ulcer covered by a fibrous membrane “cap” that looks yellowish-white or gray with well defined margins.

The ulcer is typically surrounded by a characteristic red halo due to inflammation in neighbouring blood vessels.

Aphthous ulcers are usually mildly painful and annoying, with individual lesions measuring a few millimeters across and healing within 7 to 10 days without scarring. And these usually recur 3-4 times per year.

There are some variations on this general pattern. Some individuals have recurrent aphthous ulcers which is where the recurrence is more frequent - sometimes each month, and this starts during childhood and resolves around age 40.

Another variation is major aphthous ulcers which describes lesions that measure over one centimeter in size and are generally more painful, last longer, and recur frequently.

Major aphthous ulcers can take between 10 days to over a month to heal, and can also leave a scar.

Finally there are herpetiform ulcers, which typically affect women, and despite their name are not linked in any way to the herpes virus.

Herpetiform ulcers start out as clusters of tiny discrete ulcers that coalesce to form large, ulcerated patches in the mouth.

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  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
  5. "Recurrent aphthous stomatitis" Journal of Oral and Maxillofacial Pathology (2011)
  6. "Innate immune system is implicated in recurrent aphthous ulcer pathogenesis" Journal of Oral Pathology & Medicine (2003)