Approach to adnexal masses: Clinical sciences

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A 60-year-old woman presents to the clinic with a 3-month history of worsening pelvic pressure and bloating. Her last menstrual period was 10 years ago, and she has not had postmenopausal bleeding. She has no nausea or vomiting, but does note recent constipation. Her past medical history is notable for hypothyroidism, and her medications include levothyroxine, a daily multivitamin, and a calcium supplement. Family history is significant for a maternal aunt with breast cancer at age 68. Temperature is 36.5°C (97.7°F), pulse is 72/min, respirations are 18/min, blood pressure is 120/80 mmHg, and body mass index is 34 kg/m2. The abdominal exam reveals mild distension, but no tenderness to palpation. A large pelvic mass is palpable on bimanual exam. A pelvic ultrasound shows a 12 cm multiloculated cystic structure in the left adnexa, with thick septal walls that lack internal vascularity. The mass has no mural nodules, papillary projections, or solid components. The uterus is small, and the endometrial thickness is 6 mm (slightly thicker than what is usually seen in postmenopausal women). Which of the following is the most appropriate next step in the evaluation? 

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Adnexal masses arise from the ovary, fallopian tube, or surrounding tissues. They may be cystic or solid, simple or complex, unilateral or bilateral. Most of these masses are benign, but an important diagnostic goal is to rule out malignancy. There are many types of adnexal masses, ranging from simple functional ovarian cysts to ovarian malignancy.

When a patient presents with an adnexal mass, the first step is to perform a CABCDE assessment. If the patient is unstable, control hemorrhage; stabilize airway, breathing, and circulation; obtain IV access; and monitor vital signs. Next, perform a focused history and physical examination, order an hCG to assess for pregnancy, and quickly obtain a pelvic ultrasound.

If the hCG test is positive, think about a ruptured ectopic pregnancy. In this case, the history will reveal unilateral pelvic pain, and possibly vaginal bleeding. The patient may report a history of fallopian tube injury, such as prior pelvic inflammatory disease or tubal surgery, and may report a delayed or missed last menstrual cycle. The physical examination may include abdominal or pelvic tenderness with possible rebound pain and guarding, and possibly an adnexal mass.

The ultrasound will demonstrate the absence of an intrauterine pregnancy and possibly an adnexal mass. In this case, consider an ectopic pregnancy and perform an operative laparoscopy. If on laparoscopy, you find an extrauterine pregnancy with bleeding or a ruptured fallopian tube, as well as intraperitoneal blood and clot, the diagnosis is a ruptured ectopic pregnancy.

As a clinical pearl: remember that methotrexate is contraindicated in unstable patients!

Okay, if the hCG is negative in unstable patients, they might have an adnexal torsion or a ruptured hemorrhagic cyst. The patient may report fever, nausea, and vomiting. The physical exam will reveal abdominal tenderness with possible rebound pain or guarding, and possibly a pelvic mass.

The ultrasound will show an adnexal mass, which represents an enlarged ovary, possibly with absent Doppler flow to the ovarian vessels; or free fluid in the pelvis. In this case, consider adnexal torsion or a ruptured cyst and perform an operative laparoscopy.

Sources

  1. "ACOG Practice Bulletin no. 228: Management of Symptomatic Uterine Leiomyomas" Obstet Gynecol (2021)
  2. "ACOG Committee Opinion no. 783: Adnexal Torsion in Adolescents" Obstet Gynecol (2019)
  3. "ACOG Practice Bulletin no.193: Tubal Ectopic Pregnancy" Obstet Gynecol (2018)
  4. "ACOG Practice Bulletin no.174: Evaluation and Management of Adnexal Masses" Obstet Gynecol (2016)
  5. "ACOG Committee Opinion no. 478: Family History as a Risk Assessment Tool" Obstet Gynecol (2011)
  6. "ACOG Practice Bulletin no. 114: Management of Endometriosis" Obstet Gynecol (2010)
  7. "Characteristics and Management of Ovarian Torsion in Premenarchal Compared With Postmenarchal Patients" Obstet Gynecol (2015)
  8. "Management of the adnexal mass" Obstet Gynecol (2011)
  9. "Long-term Results for Expectant Management of Ultrasonographically Diagnosed Benign Ovarian Teratomas" Obstet Gynecol (2017)
  10. "Endometriomas: their ultrasound characteristics" Ultrasound Obstet Gynecol (2010)
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