Asplenia
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Asplenia
Pathology
General infections
Sepsis
Neonatal sepsis
Abscesses
Hypersensitivity reactions
Type I hypersensitivity
Food allergy
Anaphylaxis
Asthma
Type II hypersensitivity
Immune thrombocytopenic purpura
Autoimmune hemolytic anemia
Hemolytic disease of the newborn
Goodpasture syndrome
Rheumatic heart disease
Myasthenia gravis
Graves disease
Pemphigus vulgaris
Type III hypersensitivity
Serum sickness
Systemic lupus erythematosus
Poststreptococcal glomerulonephritis
Type IV hypersensitivity
Graft-versus-host disease
Contact dermatitis
Transplants
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Graft-versus-host disease
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Immunodeficiences
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
Common variable immunodeficiency
IgG subclass deficiency
Hyperimmunoglobulin E syndrome
Isolated primary immunoglobulin M deficiency
Thymic aplasia
DiGeorge syndrome
Severe combined immunodeficiency
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Wiskott-Aldrich syndrome
Leukocyte adhesion deficiency
Chediak-Higashi syndrome
Chronic granulomatous disease
Complement deficiency
Hereditary angioedema
Asplenia
Immune system organ disorders
Thymoma
Ruptured spleen
Immune system pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
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Asplenia
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First Aid
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Asplenia
Howell-Jolly bodies p. 424
target cells p. 423
Hyposplenia p. 424
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Summary
Asplenia refers to the absence of the spleen. It can be anatomically absent, or present but without normal functioning, a condition known as functional asplenia. Asplenia can be congenital, like when it fails to develop during embryological development. It can also be acquired, usually as a result of abdominal trauma, or surgical removal.
The main function of the spleen is to filter and process old red blood cells. It also offers immunological protection against encapsulated microorganisms (e.g. Streptococcus pneumonia, Haemophilus influenzae, Neisseria meningitidis, �). So, asplenia increases susceptibility to infections with encapsulated bacteria, such as pneumococcal pneumonia and meningitis.
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