Type I hypersensitivity
Type II hypersensitivity
Immune thrombocytopenic purpura
Autoimmune hemolytic anemia
Hemolytic disease of the newborn
Rheumatic heart disease
Type III hypersensitivity
Systemic lupus erythematosus
Type IV hypersensitivity
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Selective immunoglobulin A deficiency
Common variable immunodeficiency
IgG subclass deficiency
Hyperimmunoglobulin E syndrome
Isolated primary immunoglobulin M deficiency
Severe combined immunodeficiency
Adenosine deaminase deficiency
Hyper IgM syndrome
Leukocyte adhesion deficiency
Chronic granulomatous disease
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
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Howell-Jolly bodies p. 424
target cells p. 423
Asplenia refers to the absence of the spleen. It can be anatomically absent, or present but without normal functioning, a condition known as functional asplenia. Asplenia can be congenital, like when it fails to develop during embryological development. It can also be acquired, usually as a result of abdominal trauma, or surgical removal.
The main function of the spleen is to filter and process old red blood cells. It also offers immunological protection against encapsulated microorganisms (e.g. Streptococcus pneumonia, Haemophilus influenzae, Neisseria meningitidis, �). So, asplenia increases susceptibility to infections with encapsulated bacteria, such as pneumococcal pneumonia and meningitis.
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