Atrioventricular block

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Atrioventricular block




Atrioventricular block


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Atrioventricular block

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A 14-year-old girl presents to the emergency department with lightheadedness. Since last night, she has felt fatigued and has noticed that every time she stands, she feels like she is about to pass out. She reports feeling short of breath after climbing a set of stairs for the past week. One month ago, she returned from summer camp in New Jersey, after which she began to develop fatigue and headaches. She takes acetaminophen for the headaches. Her temperature is 37.8°C (100°F), pulse is 40/min, respirations are 20/min, and blood pressure is 90/60 mmHg. She appears exhausted. Physical exam shows regular bradycardia without murmurs. No skin lesions are seen. An ECG is obtained and shows the following:  

Reproduced from: Wikimedia Commons

Which of the following species most likely transmitted this patient’s disease?  

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Wenckebach AV block p. 300


Each heartbeat starts with the heart’s pacemaker cells in the sinoatrial node, sometimes just called the SA node, in the right atrium. The SA node sends an electrical signal that propagates out through the walls of the heart and contracts both upper chambers, then moves through the atrioventricular node, or AV node, where the signal stops for a split second. Next, the signal goes down into the lower chambers, where it moves down the bundle of His, into the left and right bundle branches, and into each ventricles’ Purkinje fibers, causing them to contract as well. So, in a healthy heart, the upper chambers contract first, and then shortly after, the lower chambers contract.

On an ECG, the atrial contraction is seen as a “P wave,” and the ventricular contraction is seen as the “QRS complex.” The interval from the start of the P wave to the start of the QRS complex is called the “PR interval,” and is normally between 120 and 200 milliseconds, or 3-5 tiny boxes on the graph paper that it’s usually printed out on, since each box is 40 milliseconds or 0.04 seconds. Heart block describes a type of arrhythmia, or abnormal rhythm, that happens when the electrical signal gets delayed or blocked entirely at some point along the conduction system.

These blocks and delays usually happen because of some sort of damage or fibrosis to the electrical conduction system, the pathways that conduct the electrical signal. Lev’s disease, or Lenegre-lev syndrome, describes the large proportion of cases that are idiopathic and described as progressive cardiac conduction defects. This means it’s not clear exactly what causes it, but over time fibrosis, or scarring, develops in the conduction system which can delay or stop electrical conduction. This is usually a result of the aging process in the heart, and happens most often in the elderly, although some hereditary forms have been identified and can happen in younger people. However, another large proportion of cases are a result of ischemic heart disease, which is when the heart cells don’t receive enough oxygen and can die off, as with a heart attack. This again leaves scar tissue that can block the electrical signal. In fact, it’s estimated that about 20 percent of patients that have a heart attack go on to develop a heart block.


  1. "Type I Wenckebach second-degree AV block: A matter of definition" Clinical Cardiology (2018)
  2. "Risk Factors Associated With Atrioventricular Block" JAMA Network Open (2019)
  3. "Vagally mediated atrioventricular block: pathophysiology and diagnosis" Heart (2013)
  4. "Robbins Basic Pathology" Elsevier (2017)
  5. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  6. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)

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