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Type I hypersensitivity
Autoimmune hemolytic anemia
Hemolytic disease of the newborn
Rheumatic heart disease
Type II hypersensitivity
Systemic lupus erythematosus
Type III hypersensitivity
Type IV hypersensitivity
Common variable immunodeficiency
Hyperimmunoglobulin E syndrome
IgG subclass deficiency
Isolated primary immunoglobulin M deficiency
Selective immunoglobulin A deficiency
Adenosine deaminase deficiency
Hyper IgM syndrome
Severe combined immunodeficiency
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Chronic granulomatous disease
Leukocyte adhesion deficiency
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Autoimmune hemolytic anemia
0 / 5 complete
|Mean corpuscular volume (MCV)||88 fL|
|Blood, plasma, serum|
|Lactate dehydrogenase (LDH)||1380 U/L|
cephalosporins p. 186
autoimmune hemolytic anemia and p. 417
And this results in a lower than normal amount of red blood cells anemia.
The disease is most often idiopathic, or without a known cause, but it can be related to a medication side effect, or an underlying disease process.
Normally, red blood cells, or RBCs, are made in the bone marrow and contain hemoglobin, which is an oxygen binding protein that delivers oxygen to tissues.
Now, autoimmune hemolytic anemia is an extrinsic type of hemolytic anemia, because the immune system mistakenly believes our own red blood cells are foreign, or non-self, structures, so it secretes antibodies against proteins found on the RBC membrane.
If there had been a primary defect in the RBC membrane, then it would have been called an intrinsic hemolytic anemia.
And usually, hemolysis happens in the spleen or liver, so this is considered an extravascular hemolytic anemia - although in severe cases, RBC hemolysis can also happen intravascularly, or inside blood vessels.
Now, autoimmune hemolytic anemia gets classified as either warm or cold.
Warm is the more common type, and it’s when hemolysis occurs at temperatures greater than or equal to core human body temperature of 37º celsius.
Cold autoimmune hemolytic anemia is much rarer, and it occurs when people’s blood is exposed to cold temperatures, usually in the range of 0º to 10º celsius - like when a person goes out into cold weather during winter.
Autoimmune hemolytic anemia (AIHA) is a blood disorder that occurs when a person's own antibodies attack and destroy healthy red blood cells. The cause is not completely understood, but it may be associated with other conditions such as an infection, or leukemia. AIHA causes several symptoms, including fatigue, jaundice, shortness of breath, and an enlarged spleen.
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