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Alcohol-induced liver disease
Alpha 1-antitrypsin deficiency
Benign liver tumors
Cholestatic liver disease
Non-alcoholic fatty liver disease
Primary biliary cirrhosis
Primary sclerosing cholangitis
Pancreatic neuroendocrine neoplasms
Familial adenomatous polyposis
Juvenile polyposis syndrome
Small bowel ischemia and infarction
Protein losing enteropathy
Short bowel syndrome (NORD)
Small bowel bacterial overgrowth syndrome
Diverticulosis and diverticulitis
Irritable bowel syndrome
Cleft lip and palate
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Gastroesophageal reflux disease (GERD)
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Dental caries disease
Gingivitis and periodontitis
Temporomandibular joint dysfunction
Appendicitis: Pathology review
Cirrhosis: Pathology review
Colorectal polyps and cancer: Pathology review
Congenital gastrointestinal disorders: Pathology review
Diverticular disease: Pathology review
Esophageal disorders: Pathology review
Gallbladder disorders: Pathology review
Gastrointestinal bleeding: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Inflammatory bowel disease: Pathology review
Jaundice: Pathology review
Malabsorption syndromes: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
Pancreatitis: Pathology review
Viral hepatitis: Pathology review
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autoantibody p. 115
So an autoimmune disease is this special sort of disease where your own immune cells have gone rogue and start to attack your own cells, right?
Hepatitis happens to mean inflammation of the liver, so it’s reasonable to say that autoimmune hepatitis is this resulting inflammation of the liver tissue because they’re being attacked by your own immune cells.
Like many autoimmune diseases, the root cause of autoimmune hepatitis is ultimately not super clear, but some researchers think it’s a combination of environmental triggers and genetic predisposition.
It tends to occur most often in young women, and the female to male ratio is around 4:1.
Also though, an important piece of the genetic puzzle is the human leukocyte antigen system, shortened to HLA, which is this location of genes on chromosome 6 that regulate our immune functions.
Specifically, these genes control the proteins that are encoded and used on the cell’s surface to present foreign molecules to the immune system, so although they present antigens, they’re also a form of antigen themselves, but they aren’t the same type of antigen as one on an infectious molecule, but actually alloantigens that vary from person to person and are our specific “self-proteins”.
Usually, our thymus makes sure the T cells that attack these self proteins aren’t allowed to survive, in autoimmune disease, there may be some abnormality associated with specific self-proteins that lets the T cells attack.
Based on studying people with autoimmune hepatitis, they often have HLA- DR3 and DR4, which are both MHC class II surface receptors.
The DR part refers to its location on the chromosome, for example, depending on the location, you could have HLA-A, HLA-B, HLA-C or HLA D, and HLA-D has three subregions: P, Q, R, so this one is HLA-DR.
So there seems to be some sort of connection between these particular “self-proteins” and mounting an attack against your own liver.
Autoimmune hepatitis also tends to be associated with other diseases like Hashimoto’s thyroiditis, where your immune cells attack your thyroid, and Grave’s disease where your thyroid overproduces thyroid hormones.
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