Skip to content

Azoles

Videos

Notes

Emergency medicine

Medical and surgical emergencies

Cardiology, cardiac surgery and vascular surgery
Dermatology and plastic surgery
Endocrinology and ENT (Otolaryngology)
Gastroenterology and general surgery
Hematology and oncology
Infectious diseases
Nephrology and urology
Neurology and neurosurgery
Pulmonology and thoracic surgery
Rheumatology and orthopedic surgery

Assessments
Azoles

Flashcards

0 / 11 complete
Flashcards

Azoles

11 flashcards
Memory Anchors and Partner Content
External References
Transcript

Content Reviewers:

Yifan Xiao, MD

The “azole” antifungals are a family of medications used to treat mycoses, or fungal infections.

Mycoses can be superficial, like on the skin or hair, or develop into systemic infections in immunodeficient people.

Antifungals work either through fungistatic action, meaning that they inhibit fungal growth, or through fungicidal action, meaning they kill the fungi.

Azoles are divided into two major families of antifungals: imidazoles and triazoles.

Most fungal cells have a tough outer cell wall and an inner cell membrane.

The cell membrane is mostly made of phospholipids with some sterol or modified steroid molecules mixed in.

Humans have cholesterol, while fungi have ergosterol.

Both sterol molecules help keep the cell membrane stable at a wide range of temperatures.

Now, the precursor to both molecules is lanosterol.

Fungi have a cytochrome p450 enzyme called fourteen-alpha-demethylase in their mitochondria and endoplasmic reticulums, which converts lanosterol to ergosterol.

Without ergosterol, the structure of the cell membrane will be disrupted.

This will cause membrane-bound proteins, like ion channels, to stop working properly.

The membrane also becomes fragile, which eventually leads to inhibition of fungal growth.

The azole antifungals include imidazoles, like clotrimazole, isoconazole, miconazole, butoconazole, fenticonazole, and ketoconazole; as well as triazoles like fluconazole, itraconazole and voriconazole.

The only difference between the two groups is the imidazoles contain an imidazole ring, while triazoles contain triazole rings.

These medications work by inhibiting the fourteen-alpha-demethylase enzyme.

However, they also inhibit human cytochrome P450 enzymes to a lesser degree.

Because of this, the vast majority of azoles come in topical form, and they’re commonly used to treat superficial mycoses.

Azole creams are used for treating dermatophytosis, or ringworm, which is a red, itchy, scaly, circular rash, on the feet, groin, or armpit area, caused by Trichophyton fungus.

These fungi are also responsible for the more common “athlete’s foot” or “jock itch”.

Additionally, azoles can be used to treat tinea versicolor, caused by Malassezia globosa.

This disease is characterized by hypopigmentation or hyperpigmentation in patches of skin.

Last but not least, topical azoles are also used to treat yeast infections, such as oral or vaginal candidiasis caused by Candida species.

Topical use of azole antifungals is generally considered to be safe, since absorption through the skin is minimal, and the most common side effect is skin irritation.

Summary

Azoles are synthetic antifungals with broad spectrum activity against various fungal infections. Azoles bind to the ergosterol molecule in the fungal cell membrane and cause holes to form, which damages the cell membrane and eventually kills the fungus. Examples of azoles include drugs like clotrimazole, fluconazole, and itraconazole. Some of the side effects of azoles include nausea and vomiting, gynecomastia, and hepatotoxicity.

Sources
  1. "Katzung & Trevor's Pharmacology Examination and Board Review,12th Edition" McGraw-Hill Education / Medical (2018)
  2. "Rang and Dale's Pharmacology" Elsevier (2019)
  3. "Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition" McGraw-Hill Education / Medical (2017)
  4. "Therapeutic tools for oral candidiasis: Current and new antifungal drugs" Medicina Oral Patología Oral y Cirugia Bucal (2019)
  5. "Adverse interactions between antifungal azoles and vincristine: review and analysis of cases" Mycoses (2011)