00:00 / 00:00
Selective Beta-1 Blockers
Beta-adrenergic blockers, or just beta blockers, are a group of medications that are mainly used to treat cardiovascular conditions like hypertension, coronary artery disease and its manifestations like angina pectoris and myocardial infarction, as well as heart failure and arrhythmias. Beta blockers can also be used to treat essential tremor, glaucoma, and as prophylactic treatment of migraine attacks.
Now, beta blockers work by blocking beta receptors, of which there are three types, known as beta 1, which are mainly found in the heart and kidneys; beta 2, found in the lung bronchioles as well as the arteries of skeletal muscles; and beta 3, found in adipose tissue.
So beta blockers are classified into two main groups; nonselective and selective. Nonselective beta blockers can block both beta 1 and beta 2 receptors, and include nadolol, propranolol, pindolol, and sotalol.
On the other hand, selective beta blockers only block beta 1 receptors, and include atenolol, metoprolol, carvedilol, and nebivolol. So keep in mind that all beta blockers end in -lol, (which is pretty funny) and they can be administered orally, intravenously, or even via the ophthalmic route.
Once administered, beta blockers block beta receptors, thereby preventing the catecholamines norepinephrine and epinephrine from binding and activating them. As a result, beta blockers decrease the sympathetic nervous system response.
Latest on COVID-19
Nurse Practitioner (NP)
Physician Assistant (PA)
Create custom content
Raise the Line Podcast
Copyright © 2024 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Cookies are used by this site.
Terms and Conditions
USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.