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Blood pressure, blood flow, and resistance
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α-blocker effect on p. 245
angiotensin II effects p. 612, 612
antianginal therapy p. 326
antidiuretic hormone regulation of p. 340
cortisol effect on p. 337
fenoldopam and p. 325
renal disorders and p. 615
renin-angiotensin-aldosterone system p. 612
sympathomimetic effect on p. 244
Pressure is a force over an area, so with blood pressure, we’re measuring the force that the blood exerts on the surface area of the walls of the blood vessels. Differences in blood pressure throughout the body keep blood flowing from high-pressure areas, like the arteries, to low-pressure areas, like the veins. When we say “blood flow,” we’re referring to the volume of blood that flows through a vessel or an organ over some period of time. Now, the amount of blood flow from one end of a blood vessel to another is affected by the blood pressure, and by the resistance, which comes from the vessels themselves. Vasoconstriction, where the vessels constrict, decreases blood flow, and vasodilation, where the blood vessels expand, increases blood flow.
Now, blood flow is not the same thing as the velocity of blood. Blood flow is the volume of blood that moves by a point over some period of time. So let’s say this chunk of blood has a volume of 83 cm^3, and it took 1 second for this much to flow past the blue circle—this is the blood flow, represented by the variable capital Q.
Now, velocity on the other hand, is the distance traveled in a certain amount of time. So maybe in the same one second, a red blood cell at the very edge here traveled a distance of 27 cm, then it’d be moving 27 cm/s, represented by lowercase v. Even though these aren’t equal, they are related, and the last piece is area, specifically the cross-sectional area of the blood vessel, which in reality is the same as the blood cross section like this. So, based on units, since area’s going to be expressed in cm^2, we see that flow rate equals area times velocity! Alright, so for example, let’s say we want to calculate blood velocity, and we have a person’s cardiac output of 5L/min, which is average for an adult, and the diameter of their aorta, which is 2cm.
Blood pressure is the force your circulating blood exerts against the walls of your arteries. Blood flow is the movement of blood through your body, and resistance is the pushback that's against the blood flow in the circulatory system. Blood pressure, flow, and resistance are all closely related. Your blood pressure is determined by two things: the amount of blood flowing through your arteries and the diameters (widths) of those vessels. The more blood that flows through the arteries and the narrower those vessels are, the higher your blood pressure will be.
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