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Bone remodeling and repair

Bone remodeling and repair


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High Yield Notes
9 pages

Bone remodeling and repair

11 flashcards

USMLE® Step 1 style questions USMLE

3 questions

A group of scientists is evaluating the effects of estrogen on bone remodeling in an attempt to find new treatments for osteoporosis. In their study, estrogen deficiency is associated with an increased risk of osteoporosis. Which of the following is true regarding the effects of estrogen on  bone remodeling?  


Bone remodeling is when old, brittle bone tissue is removed or resorbed and gets replaced by new bone tissue. Remodeling also occurs when reshaping your bones after a fracture or when repairing micro-cracks which form during ordinary activities, especially when your bones are under stress, like after lifting heavy weights.

Now the surface of the bones is covered by this layer called the periosteum, except at the articular cartilages, which are the parts involved in the joints. The periosteum consists of an outer fibrous layer which protects the bones and provides attachment for the tendons and the ligaments, and it also has an inner cellular layer which houses progenitor stem cells. These progenitor stem cells develop into both osteoblasts which secrete the bone matrix, and chondroblasts - which produce cartilage.

Now let’s look at the femur - the longest bone in the body. The two ends of the bone that form the joints are called epiphysis, while the shaft of the bone is called the diaphysis. Looking at the diaphysis, it has an external part; the cortical bone, which consists of many tiny cylinders known as osteons.

Each osteon is made of many lamellae, which are these concentric layers made of an organic part - mostly collagen, and an inorganic part called hydroxyapatite, which is mostly calcium phosphate. In the center of every osteon is a Haversian canal, which contains the blood supply and innervation for the bone cells. In the center of the bone, is the medullary canal - a hollow space lined by a honeycomb-looking structure called the spongy or cancellous bone. The medullary canal contains the bone marrow, which is the site of blood cell production.

Now, the epiphysis is made of a lot of spongy bone. And when you look closer at the spongy bone, it’s made of crosslinking tiny roads called trabeculae, which make your bones resistant to mechanical stress, so that they can bear weights without caving in. And just like the medullary cavity, the spaces in the spongy bone of the epiphysis are occupied by bone marrow.

Now, let’s jump into the bone. That’s where we find two kinds of stem cells – the mesenchymal stem cells, which give rise to osteoprogenitor cells; and the hematopoietic stem cells, the blood-making cells of the bone marrow.

Mesenchymal stem cells are also found in the bone canals, endosteum, and periosteum, and differentiate into osteoblasts. The hematopoietic stem cells give rise to the lymphoid progenitor cells - which mature and differentiate into lymphocytes like T and B cells, the main cells involved in your adaptive immunity; and the myeloid progenitor cells, which differentiate into red blood cells, platelets, and myeloblasts – the progenitors of basophils, neutrophils, eosinophils and monocytes. There are a number of growth factors that help these cells develop. For example, osteoblasts release a substance called M-CSF - Macrophage colony-stimulating factor, which helps stimulate myeloid cells like monocytes.

Now in bone remodeling, the process begins when osteoblasts sense micro cracks at their location, like when your bones are bearing too much weight. The osteoblasts produce a substance called RANKL - receptor activator of nuclear factor κβ ligand, which binds to RANK receptors on the surface of nearby monocyte precursor cells.

  1. "Medical Physiology" Elsevier (2016)
  2. "Physiology" Elsevier (2017)
  3. "Human Anatomy & Physiology" Pearson (2018)
  4. "Principles of Anatomy and Physiology" Wiley (2014)
  5. "Cellular and Molecular Mechanisms of Bone Remodeling" Journal of Biological Chemistry (2010)
  6. "Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit" BoneKEy Reports (2014)