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Bone tumors: Pathology review

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Pathology

Musculoskeletal system

Pediatric musculoskeletal conditions
Musculoskeletal injuries and trauma
Bone disorders
Joint disorders
Muscular disorders
Neuromuscular junction disorders
Other autoimmune disorders
Musculoskeletal system pathology review

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Bone tumors: Pathology review

Questions

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Questions

USMLE® Step 1 style questions USMLE

9 questions
Preview

A 67-year-old man comes to the clinic due to progressive fatigue and back pain over the past few months. Initially, the patient attributed the pain to strenuous work in the garden but decided to seek care when he noticed no improvement. The patient also noted a 10 lb (4.5 kg) weight loss without changes in his diet. Medical history is significant for smoking 1 pack of cigarettes per day for 35 years and diabetes mellitus type 2. Laboratory values are obtained and shown below:  
 

 Laboratory value  Result 
 Hemoglobin  11.2 g/dL 
 Mean corpuscular hemoglobin   90 fl 
 Creatinine   2.3 mg/dL 
 Total protein  9.5 
 Albumin  3.2 g/dL 
 Sodium   132 mEq/L 
 Potassium   4.2 mEq/L 
 Chloride   95 mEq/L 
 Calcium  12 mg/dl  

Radiograph of the spine reveals multiple areas of hyperlucency at the lumbar and thoracic regions. Which of the following is the most likely underlying cause?