00:00 / 00:00
Bacterial structure and functions
Streptococcus pyogenes (Group A Strep)
Streptococcus agalactiae (Group B Strep)
Clostridium botulinum (Botulism)
Clostridium difficile (Pseudomembranous colitis)
Clostridium tetani (Tetanus)
Bacillus cereus (Food poisoning)
Corynebacterium diphtheriae (Diphtheria)
Bacillus anthracis (Anthrax)
Salmonella typhi (typhoid fever)
Legionella pneumophila (Legionnaires disease and Pontiac fever)
Yersinia pestis (Plague)
Vibrio cholerae (Cholera)
Francisella tularensis (Tularemia)
Bordetella pertussis (Pertussis/Whooping cough)
Haemophilus ducreyi (Chancroid)
Mycobacterium tuberculosis (Tuberculosis)
Mycobacterium avium complex (NORD)
Borrelia burgdorferi (Lyme disease)
Borrelia species (Relapsing fever)
Treponema pallidum (Syphilis)
Rickettsia rickettsii (Rocky Mountain spotted fever) and other Rickettsia species
Coxiella burnetii (Q fever)
Ehrlichia and Anaplasma
Gardnerella vaginalis (Bacterial vaginosis)
0 / 11 complete
0 / 1 complete
Alexandru Duhaniuc, MD
Brucella is a genus of Gram-negative coccobacilli, and it groups together several species including Brucella abortus, Brucella melitensis, Brucella canis and Brucella suis.
All cause a systemic disease called brucellosis, but each of them has a different host, and causes a different form of the disease.
Now, Brucella it’s a non-motile bacteria that doesn’t form spores.
It’s a strict aerobe, meaning that it needs oxygen to survive, and also, it’s facultative intracellular which means it can survive both inside and outside the cell.
Finally, it’s urease and catalase positive which means it produces both these enzymes.
Brucella is usually isolated on blood cultures, with biphasic methods like the Ruiz-Castaneda methods.
Biphasic means that the blood culture bottle has both a solid phase, and a liquid phase.
Now, Brucella is a very slow growing bacteria, so colonies usually grow in the solid medium after 6 to 8 weeks of incubation.
The colonies are raised, convex with smooth, shiny corners.
On the bright side, there are now some modern automated blood culture systems called the Bactec systems, which are more effective and can isolate Brucella after only 1 week. Neat!
Now, Brucella can enter the body one of two ways.
First, there may be direct contact with infected animals - and the host is different for each Brucella species.
So, B. abortus is transmitted by cattle, B. melitensis is transmitted by small ruminants such as goats and sheep, B. canis is transmitted by dogs and B. suis is transmitted by swine and rodents.
In this case the bacteria enters through skin lesions, mucous membranes and inhalation.
The second way is ingestion of contaminated animal products such as unpasteurized milk, cheese and undercooked meat.
So, once the bacteria is inside the bloodstream, it’s ingested by phagocytes like macrophages and neutrophils.
Normally, phagocytes destroy invading bacteria by wrapping them up in vesicles called phagosomes, which will merge with lysosomes to form a phagolysosome.
Lysosomes are round vesicles that contain hydrolytic enzymes, which are released inside the phagolysosome to destroy the invading bacteria.
However, Brucella has a few virulence factors that it uses to avoid destruction.
Brucella is a gram-negative coccobacilli that can infect humans and animals. It is the cause of brucellosis, which is a zoonotic disease that can lead to fever, arthritis, and death. There are four main species of Brucella that cause disease in humans: Brucella abortus, Brucella melitensis, Brucella suis, and Brucella canis. Symptoms of brucellosis include fever, headache, myalgia, fatigue, and there may be lymphadenopathy and hepatosplenomegaly.
Copyright © 2023 Elsevier, except certain content provided by third parties
Cookies are used by this site.
USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.