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Bacterial structure and functions
Bacillus anthracis (Anthrax)
Bacillus cereus (Food poisoning)
Corynebacterium diphtheriae (Diphtheria)
Clostridium botulinum (Botulism)
Clostridium difficile (Pseudomembranous colitis)
Clostridium tetani (Tetanus)
Streptococcus agalactiae (Group B Strep)
Streptococcus pyogenes (Group A Strep)
Bartonella henselae (Cat-scratch disease and Bacillary angiomatosis)
Legionella pneumophila (Legionnaires disease and Pontiac fever)
Salmonella typhi (typhoid fever)
Yersinia pestis (Plague)
Vibrio cholerae (Cholera)
Bordetella pertussis (Pertussis/Whooping cough)
Francisella tularensis (Tularemia)
Haemophilus ducreyi (Chancroid)
Gardnerella vaginalis (Bacterial vaginosis)
Coxiella burnetii (Q fever)
Ehrlichia and Anaplasma
Rickettsia rickettsii (Rocky Mountain spotted fever) and other Rickettsia species
Borrelia burgdorferi (Lyme disease)
Borrelia species (Relapsing fever)
Treponema pallidum (Syphilis)
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All cause a systemic disease called brucellosis, but each of them has a different host, and causes a different form of the disease.
Now, Brucella it’s a non-motile bacteria that doesn’t form spores.
It’s a strict aerobe, meaning that it needs oxygen to survive, and also, it’s facultative intracellular which means it can survive both inside and outside the cell.
Finally, it’s urease and catalase positive which means it produces both these enzymes.
Brucella is usually isolated on blood cultures, with biphasic methods like the Ruiz-Castaneda methods.
Biphasic means that the blood culture bottle has both a solid phase, and a liquid phase.
Now, Brucella is a very slow growing bacteria, so colonies usually grow in the solid medium after 6 to 8 weeks of incubation.
The colonies are raised, convex with smooth, shiny corners.
On the bright side, there are now some modern automated blood culture systems called the Bactec systems, which are more effective and can isolate Brucella after only 1 week. Neat!
First, there may be direct contact with infected animals - and the host is different for each Brucella species.
So, B. abortus is transmitted by cattle, B. melitensis is transmitted by small ruminants such as goats and sheep, B. canis is transmitted by dogs and B. suis is transmitted by swine and rodents.
In this case the bacteria enters through skin lesions, mucous membranes and inhalation.
The second way is ingestion of contaminated animal products such as unpasteurized milk, cheese and undercooked meat.
Normally, phagocytes destroy invading bacteria by wrapping them up in vesicles called phagosomes, which will merge with lysosomes to form a phagolysosome.
Lysosomes are round vesicles that contain hydrolytic enzymes, which are released inside the phagolysosome to destroy the invading bacteria.
However, Brucella has a few virulence factors that it uses to avoid destruction.
Brucella is a gram-negative coccobacilli that can infect humans and animals. It is the cause of brucellosis, which is a zoonotic disease that can lead to fever, arthritis, and death. There are four main species of Brucella that cause disease in humans: Brucella abortus, Brucella melitensis, Brucella suis, and Brucella canis. Symptoms of brucellosis include fever, headache, myalgia, fatigue, and there may be lymphadenopathy and hepatosplenomegaly.
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