Brugada syndrome

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Brugada syndrome

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$NOTES NOTES SUDDEN CARDIAC DEATH GENERALLY, WHAT IS IT? PATHOLOGY & CAUSES ▪ Abrupt cessation of cardiac activity (cardiac arrest) in someone asymptomatic up until moment of arrest SIGNS & SYMPTOMS ▪ Asymptomatic DIAGNOSIS TREATMENT MEDICATIONS ▪ According to Advanced Cardiac Life Support protocols OTHER INTERVENTIONS Cardiopulmonary resuscitation (CPR) ▪ Maintains blood ﬂow by mimicking pumping motion heart makes during a medical emergency ▪ Made based on lack of pulse BRUGADA SYNDROME osms.it/brugada-syndrome PATHOLOGY & CAUSES ▪ Condition with characteristic abnormal electrocardiogram ﬁndings → increases risk of sudden cardiac death in healthy individuals ▪ Mixture of normal, abnormal sodium channels within adjacent myocardial tissue can set up heterogenous refractory periods necessary for development of reentrant rhythms → ventricular tachycardia/ ﬁbrillation ▪ 20% associated with SCN5A gene mutation which encodes for sodium ion channel in cell membranes of heart muscle cells RISK FACTORS ▪ Biological males, more common in Asia than North America, Europe COMPLICATIONS ▪ Ventricular ﬁbrillation, high risk of sudden cardiac death CAUSES ▪ Inherited ▫ Autosomal dominant, variable expression OSMOSIS.ORG 127$

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Brugada syndrome

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A 20-year-old man who recently immigrated from Thailand is brought to the emergency department for palpitations beginning thirty minutes ago beginning when he awoke from sleeping. He says that the palpitations were accompanied by shortness of breath and an episode of near-syncope. His medical history is non-contributory. An EKG is performed and shows slight ST elevation that is declining and is accompanied by an inverted T-wave. Within five minutes, the patient passes away and cannot be successfully resuscitated. Which of the following is the most likely cause of death?

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