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Varicella zoster virus
Poxvirus (Smallpox and Molluscum contagiosum)
Herpes simplex virus
Malassezia (Tinea versicolor and Seborrhoeic dermatitis)
Pediculus humanus and Phthirus pubis (Lice)
Sarcoptes scabiei (Scabies)
Human herpesvirus 6 (Roseola)
Varicella zoster virus
Human herpesvirus 8 (Kaposi sarcoma)
Pigmentation skin disorders: Pathology review
Acneiform skin disorders: Pathology review
Papulosquamous and inflammatory skin disorders: Pathology review
Vesiculobullous and desquamating skin disorders: Pathology review
Bacterial and viral skin infections: Pathology review
Skin cancer: Pathology review
Viral exanthems of childhood: Pathology review
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autoantibody p. 113
type II hypersensitivity p. 110
bullous pemphigoid p. 493
Stefan Stoisavljevic, MD
Evan Debevec-McKenneyJustin Ling, MD, MS
Bullous pemphigoid is an autoimmune skin disease that causes the skin to form bullae or blisters.
Now, the skin is divided into three layers--the epidermis, dermis, and hypodermis.
The epidermis forms the thin outermost layer of skin.
Underneath, is the thicker dermis layer, and finally, there’s the hypodermis that anchors the skin to the underlying muscle.
The epidermis itself is made of multiple layers of developing keratinocytes - which are flat pancake-shaped cells that are named for the keratin protein that they’re filled with.
Keratinocytes start their life at the lowest layer of the epidermis called the stratum basale, or basal layer which is made of a single layer of stem cells, called basal cells that continually divide and produce new keratinocytes.
The stratum basale also contains another group of cells called melanocytes, which secrete melanin.
Melanin is a pigment protein, or coloring substance.
Below the epidermis is the basement membrane which is a thin layer of delicate tissue containing collagen, laminins, and other proteins.
Basal cells are attached to the basement membrane by hemidesmosomes, a protein complex that stems from the bottom of the basal cells.
Just like an anchor digs into the seafloor and holds a boat in place, hemidesmosomes dig into the basement membrane and hold basal cells in place.
The exact cause of bullous pemphigoid is unclear, but it’s thought that in a person with a genetic precondition, it can be triggered by medications like furosemide, captopril, penicillamine, non steroid anti-inflammatory drugs (or NSAIDs), and antibiotics.
Bullous pemphigoid is a type II hypersensitivity reaction, which is when the immune system produces antibodies that bind to the body’s own cells.
Immune cells called B cells produce IgG antibodies, which are Y shaped molecules with 2 regions, an antigen binding fragment region - or Fab region, and fragment crystallizable region or Fc region.
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