Bundle branch block
AssessmentsBundle branch block
Bundle branch block
USMLE® Step 1 style questions USMLE
A 71-year-old man presents to the emergency department with sudden onset chest pain. He was sitting at home watching television when he noticed the pain, characterized as a sharp pressure-like sensation in the left side of his chest. He is having difficulty catching his breath. Medical history is significant for hypertension, COPD, chronic kidney disease, and coronary artery disease. He takes amlodipine, lisinopril, aspirin, salmeterol, and albuterol. His father died from a heart attack at age 50. He smokes one pack of cigarettes per day and drinks occasionally. His temperature is 37.2°C (99°F), pulse is 105/min, respirations are 23/min, blood pressure is 90/60 mmHg, and oxygen saturation is 90% on room air. He appears pale and diaphoretic. Physical exam shows a holosystolic murmur at the left mid sternal border that increases with supine leg raise. Lung examination is normal. An ECG is obtained and shows the following:
Reproduced from: Wikimedia Commons
Which of the following is the most likely cause of this patient’s symptoms?
Bundle branch block exam links
Content Reviewers:Rishi Desai, MD, MPH
Contributors:Tanner Marshall, MS, Vincent Waldman, PhD
Each heartbeat starts with the heart’s pacemaker cells in the sinoatrial node, sometimes called the SA node, in the right atrium. The SA node sends out an electrical signal that propagates out and contracts both upper chambers. The signal then moves through the atrioventricular node, or AV node, down into the lower chambers. Here it reaches the bundle of His and splits into the left and right bundle branches, which serve the left and the right ventricles. The signal then goes on to each ventricles’ Purkinje fibers, which leads to ventricular contraction.
Now, a “bundle branch block” describes when that electrical signal gets completely blocked or held up along one of the bundle branches. In most cases, this block, or delay, is caused by fibrosis, or scarring, that either occurs acutely or chronically. Acute causes can be things like ischemia, heart attack, or myocarditis, the inflammation of the heart tissue. Chronic conditions might lead to fibrosis of the heart tissue, because they all can cause slow and steady remodeling of the heart muscle; these include: hypertension, coronary artery disease, and cardiomyopathies.
If the block happens on the right side, it’s referred to as a right bundle branch block. With this type, the electrical signal starts at the SA node, contracts the atria, moves through the AV node, splits at the bundle of His, and then moves down the left bundle branch, but is blocked on the right bundle branch. This causes the left ventricle to contract first. The signal then spreads from the purkinje fibers of the left ventricle over to the right ventricle, which causes the right ventricle to contract after the left has contracted. So, with right bundle branch block, the right ventricle contracts late. If the block happened to be on the left side instead, which is called a left bundle branch block, the signal would be delayed on that side, and so the right ventricle would contract first, and then the left ventricle would contract late.
Now, on electrocardiogram or ECG, normally you have the characteristic P wave, which corresponds to the atria contracting, then the QRS complex, which corresponds to both ventricles contracting and is usually between 80 and 100 ms long. If there’s a delay in depolarization of one of the ventricles, the QRS complex gets wider because depolarization starts on time but ends later than usual. Because now one of the ventricles is contracting late, a QRS complex longer than 120 ms is common to see in a bundle branch block. Okay, so far we’ve been looking a relatively common view of the heart, called lead two, which is a type of “limb lead,” since we get it by attaching leads to two limbs: the right arm and left leg.
Even though this lead can provide some solid information, it’s often helpful to use other leads as well, especially when differentiating between left and right bundle branch block. The chest leads, or precordial leads, are really useful for doing just that. Chest leads look at the heart’s electrical activity when viewed from a slice parallel with the ground, whereas limb leads look at the heart in the frontal plane, which is perpendicular to the ground.
For chest leads, they go from V1, coming straight out the front of the chest, to V6, going out the left side of the chest. Each of these is like looking at the heart from a different perspective, right? V1 and V6 are particularly helpful since they’re the farthest apart from each other, and therefore have the most contrast between views. Normally, the first thing to depolarize is the septum, and the wave of depolarization moves from the left bundle branch toward the right ventricle, so toward V1 but away from V6. This means you’ll get a positive deflection on V1, and a negative deflection on V6. Next, that wave moves to the ventricles themselves, and since the left ventricle is usually more massive, you’ll get a large depolarization directed away from V1 but toward V6, so negative on V1 and positive on V6. Let’s say there’s a block along the left bundle branch, so now the overall direction of depolarization comes from the right side and moves toward the left, so away from V1 and toward V6, meaning negative in V1 and positive in V6. V6 will also often be notched from the left ventricle, depolarizing late. So, when it’s all said and done, V1 usually has a QS or “little r”-S complex, because QS means an absent R wave, and “little r”-S means a small R wave, either of which give it a “W” shape. On V6, the large “notched” R wave gives it an “M” shape.
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