Campylobacter jejuni

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Campylobacter jejuni

block exam 1.5.

block exam 1.5.

Anatomy of the pharynx and esophagus
Anatomy of the oral cavity
Anatomy of the salivary glands
Anatomy of the tongue
Abdominal quadrants, regions and planes
Anatomy of the abdominal viscera: Esophagus and stomach
Anatomy of the abdominal viscera: Small intestine
Anatomy of the abdominal viscera: Pancreas and spleen
Anatomy of the abdominal viscera: Large intestine
Anatomy of the abdominal viscera: Liver, biliary ducts and gallbladder
Anatomy of the anterolateral abdominal wall
Gallbladder histology
Esophagus histology
Stomach histology
Small intestine histology
Colon histology
Liver histology
Pancreas histology
Thymus histology
Spleen histology
Lymph node histology
Introduction to the immune system
Cytokines
Innate immune system
Complement system
T-cell development
B-cell development
MHC class I and MHC class II molecules
T-cell activation
B-cell activation and differentiation
Cell-mediated immunity of CD4 cells
Cell-mediated immunity of natural killer and CD8 cells
VDJ rearrangement
B- and T-cell memory
Antibody classes
Selective immunoglobulin A deficiency
Complement deficiency
Bacterial structure and functions
Bacillus cereus (Food poisoning)
Escherichia coli
Salmonella (non-typhoidal)
Vibrio cholerae (Cholera)
Campylobacter jejuni
Helicobacter pylori
Viral structure and functions
Hepatitis B and Hepatitis D virus
Hepatitis A and Hepatitis E virus
Hepatitis C virus
Norovirus
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Giardia lamblia
Mechanisms of antibiotic resistance
Cell wall synthesis inhibitors: Penicillins
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Inflammation
Contracting the immune response and peripheral tolerance
Prebiotics and probiotics
Hepatitis
Diarrhea: Clinical

Assessments

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High Yield Notes

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Campylobacter jejuni

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Questions

USMLE® Step 1 style questions USMLE

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A 36-year-old man presents to the emergency department due to difficulty ambulation for the past four days. The patient reports “stumbling” and states, “I feel like my legs are getting weaker and weaker.” The patient has no other medical history and takes no medications daily. Vitals are within normal limits. Neurologic exam is notable for 3/5 strength in the lower extremities bilaterally and a decreased patellar and Achilles reflex bilaterally. The remainder of the neurologic examination is unremarkable. This patient’s condition was most likely preceded by infection with which of the following organisms?  

External References

First Aid

2024

2023

2022

2021

Arthritis p. 472

Campylobacter jejuni p. , 143

Bloody diarrhea p. 176

Campylobacter jejuni p. , 143, 147

Campylobacter jejuni p. , 143

Gram-negative algorithm p. 139

Guillain-Barré syndrome p. 538

Cats, (disease vectors)

Campylobacter jejuni p. , 143

Diarrhea

Campylobacter jejuni p. , 143

Guillain-Barré syndrome

Campylobacter jejuni p. , 143

Reactive arthritis p. 475

Campylobacter jejuni p. , 143

Transcript

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Content Reviewers

With Campylobacter jejuni, “campylo” means curved, “bacter” means rod, while “jejuni” refers to the jejunum, which is a segment of the small intestines found between the duodenum and the ileum.

So, Campylobacter jejuni is a comma-shaped bacteria, and it’s one of the most common causes of bacterial gastroenteritis worldwide.

It's commonly found in foods like poultry, and unpasteurized milk.

Now, let’s talk microbe anatomy and physiology. Campylobacter jejuni is a comma-shaped bacteria that has a thin peptidoglycan cell wall, which doesn’t take in the purple dye when Gram stained, and instead appears pink or red – which makes it a gram-negative bacteria.

It also has a flagellum at one end which it uses to get around, so it’s a motile bacteria.

In addition to this, it’s oxidase-positive, meaning that it can use oxygen to create stored energy or ATP.

Lastly, Campylobacter jejuni is a microaerophile that loves warmth, so it grows best in low-oxygen environments, at 42 degrees Celsius, on blood agar varieties like Skirrow, Butzler, and Campy-BAP.

Alright, Campylobacter jejuni is usually transmitted from animals to humans, via the fecal-oral route.

In other words, you catch it by ingesting stool particles containing the bacteria.

Campylobacter jejuni usually resides in the gastrointestinal tract of birds.

So, when people eat raw and undercooked poultry, there's a possibility of infection.

Similarly, cows are common carriers, so people that drink unpasteurized milk can also risk infection.

There’s also direct contact with infected pets, notably puppies which excrete the bacteria in their stool.

Kids are the most susceptible to getting infected after playing with an infected pet.

Lastly, infected stool can end up in sources of freshwater, like rivers, and cause infection.

Once inside our body, Campylobacter jejuni has a number of virulence factors that it can use to attach to host cells and cause disease.

First, it has fimbriae-like filaments and cell surface proteins like PEB1 and CadF that help it attach to the mucosa of the small intestine and colon.

There, Campylobacter jejuni uses its spiral shape and long flagella to ‘drill' into the mucosa where they release toxins called cytolethal distending toxins.

These toxins damage nearby intestinal epithelium cells, further worsening the inflammation.

When the inflammation and damage becomes pretty extensive the colon might dilate, resulting in toxic megacolon.

Summary

Campylobacter jejuni is a comma-shaped gram-negative, oxidase-positive bacteria commonly found in poultry and other animals. It can cause a foodborne illness called campylobacteriosis, which is characterized by diarrhea, abdominal pain, and fever. In severe cases, the infection can spread to the bloodstream and cause life-threatening complications like sepsis. Campylobacter jejuni is most commonly spread through the feco-oral route, usually by ingesting contaminated food or water. Treatment for campylobacteriosis includes antibiotics and supportive care. Prevention of this infection includes proper hand hygiene and safe food preparation practices.