Cardiac and vascular function curves
Summary of Cardiac and vascular function curves
The cardiac function curve or the Frank-Starling curve is a plot of the relationship between cardiac output of the left ventricle and right atrial pressure. An increase in venous return of the left ventricle will increase the right atrial pressure, end-diastolic volume and end-diastolic fiber length and therefore increase cardiac output. The vascular function curve is a plot of the relationship between the venous return and right atrial pressure. An increase in right atrial pressure will decrease the pressure gradient between the systemic arteries and the right atrium and would thereby decrease the amount of venous return to the right atrium.
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Physiology
Cardiovascular system
Anatomy and physiology
Hemodynamics
Cardiac output
Cardiac cycle and pressure-volume loops
Cardiovascular physiological responses
Auscultation of the heart
Myocyte electrophysiology
Electrocardiography
Blood pressure regulation
High Yield Notes
10 pages
![NOTES NOTES CARDIAC CYCLE MEASURING CARDIAC OUTPUT FICK PRINCIPLE osms.it/Fick-principle ▪ Model used to measure cardiac output (CO) ▫ Output of left, right ventricles equal during normal cardiac function ▪ Steady state: rate of O2 consumption = amount of O2 leaving lungs via pulmonary vein - amount of O2 returning via pulmonary arteries x CO ▪ Pulmonary blood flow of right heart = CO of left heart: used to calculate CO Cardiac Output = O2 consumption [O2] pulmonary vein - [O2] pulmonary artery ▪ 250mL/minute = total O2 consumption (70kg, biologically-male individual); pulmonary venous O2 content = 0.20/mL; pulmonary arterial O2 content = 0.15/mL Cardiac Output = 250mL/min = 5000mL/min 0.20mL - 0.15mL ▪ Also measures blood flow to individual organs ▫ Renal blood flow = renal O2 consumption / renal arterial O2 - renal venous O2 CARDIAC & VASCULAR FUNCTION CURVES osms.it/cardiac-and-vascular-function-curves ▪ Curves depicting functional connections between vascular system, right atrial pressure, and CO CARDIAC FUNCTION CURVE (CO CURVE) ▪ Plot of relationship between left ventricle (LV) CO, right atrial (RA) pressure ▪ Based on Frank–Starling relationship describing CO dependence on preload ▫ Preload (determined by RA pressure), independent variable; CO, dependent variable ▫ ↑ venous return → ↑ RA pressure → ↑ LV end-diastolic volume (EDV)/preload, myocardial fiber stretch → ↑ CO ▫ LV CO (L/min) = LV venous return/ preload (RA pressure in mmHg) ▫ Relationship remains intact with steady state of venous return ▫ RA pressure 4mmHg → curve levels off at maximum 9L/min OSMOSIS.ORG 111](https://d16qt3wv6xm098.cloudfront.net/frhMThDfSAm-dds1kgRyp5irSyax-t1W/thumb-1.jpg)
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