Cardiac contractility
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High Yield Notes
7 pages
Questions
USMLE® Step 1 style questions USMLE
of complete
Summary
Contractility is the ability of the heart muscle to contract and thereby pump blood. Cardiac contractility is determined by the interaction between intracellular calcium concentration, and the myofilament cross-bridge cycling. The Frank-Starling mechanism is a key factor in determining cardiac contractility. This mechanism states that the more stretched (tensed) a heart muscle fiber is, the more calcium it will release from its stores, leading to increased contraction force.
Sources
- "Medical Physiology" Elsevier (2016)
- "Physiology" Elsevier (2017)
- "Human Anatomy & Physiology" Pearson (2017)
- "Principles of Anatomy and Physiology" Wiley (2014)
- "Effects of cardiac contractility modulation by non-excitatory electrical stimulation on exercise capacity and quality of life: An individual patient's data meta-analysis of randomized controlled trials" International Journal of Cardiology (2014)
- "Clinical effects of cardiac contractility modulation (CCM) as a treatment for chronic heart failure" European Journal of Heart Failure (2012)
- "Impact of Cardiac Contractility Modulation on Left Ventricular Global and Regional Function and Remodeling" JACC: Cardiovascular Imaging (2009)
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