AssessmentsCarpal tunnel syndrome
Carpal tunnel syndrome
USMLE® Step 1 style questions USMLE
USMLE® Step 2 style questions USMLE
A 32-year-old woman was brought to the emergency department after waking up at 2:30AM with numbness and weakness in her left hand. Upon waking, she also noticed cold sweats, palpitations, and a feeling of being unable to move her face. In the ambulance, the paramedics did not see any facial droop or ptosis. Her vitals were stable with some mild tachycardia to the low 100s. Physical examination shows decreased sensation over the palmar aspect of the thumb, index, middle, and half of the fourth digits bilaterally, and 5/5 grip strength bilaterally. She also has a positive Phalen maneuver, positive Tinel sign on the left, and a negative Finkelstein's test. The rest of the neurologic exam was noncontributory. She was diagnosed with carpal tunnel syndrome and a mild panic attack. Which of the following is the most appropriate treatment?
Content Reviewers:Rishi Desai, MD, MPH, Jessica MacEachern, MA, Kyle Slinn, MEd, RN, Tanner Marshall, MS
This compression typically causes pain, numbness, and tingling in the thumb, index finger, middle finger, and the thumb side of the ring finger, which are the areas of skin innervated by the median nerve.
Now taking a cross section of the wrist, we’ll see a bony arch known as a carpal arch on the dorsal side of the hand which forms the floor of the carpal tunnel, and a sheath of connective tissue called the flexor retinaculum or transverse carpal ligament, which is on the palmar side of the hand forms the roof of the carpal tunnel.
Also there are nine flexor tendons, which go to the fingers and thumb, as well as one nerve—the median nerve—which travels down the forearm and go through the carpal tunnel.
The skin of the hand served by the median nerve includes the thumb, the index finger, and middle finger, as well as half of the ring finger that’s on the thumb side.
Carpal tunnel syndrome is caused by compression of the median nerve, and that typically happens as a result of inflammation of the nearby tendons and tissues, which creates local edema or swelling which increases the amount of fluid in a very tight space, and essentially puts pressure on the median nerve.
Initially that pressure can cause a dull ache or discomfort in any of the areas of the hand that are innervated by the median nerve.
Eventually this discomfort can lead to sharp, pins-and-needles-like pain, called paresthesia, which can extend up the forearm.
People might also have muscle weakness which can cause clumsiness with tasks like holding small objects, turning doorknobs and keys, or fine motor tasks like buttoning up a shirt.
In severe situations, the thenar muscles at the base of the thumb can start to waste away.
This happens because those muscles are innervated by the recurrent branch of the median nerve which arises from the median nerve after it passes through the carpal tunnel.
Basically, in a nutshell, any structure innervated by the median nerve downstream of the point of compression can be affected.
Interestingly, a superficial sensory branch of the median nerve, called the palmar branch, provides sensation to the central base of the palm.
- "Robbins Basic Pathology" Elsevier (2017)
- "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
- "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
- "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
- "Diagnosing and managing carpal tunnel syndrome in primary care" British Journal of General Practice (2014)
- "The Quality and Strength of Evidence for Etiology: Example of Carpal Tunnel Syndrome" The Journal of Hand Surgery (2008)
- "Prevalence of Carpal Tunnel Syndrome in a General Population" JAMA (1999)