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Case-control studies are a type of study design that compares the history of two groups of people - those that have a certain outcome, called cases, and those that don’t have a certain outcome, called controls; to see if they’ve been exposed to different things.
Because case-control studies look at the past exposures of people with and without the outcome, this type of study is called retrospective, retro meaning past.
The opposite would be to start with people who either have the exposure or don’t have the exposure, and then follow them over time to see if they develop an outcome in the future.
That would be a prospective study.
But, following people over time can take a lot of time and cost money.
By comparison, case-control studies are often quicker and cheaper, since they use data that’s already collected or is relatively easy to collect, like medical records, employment records, or individual interviews and surveys.
For example, researchers might interview a group individuals with skin cancer and a group of individuals without skin cancer to see how many times they used tanning beds in the past five years, then compare the results.
This is particularly true when it comes to rare diseases, but the definition of “rare” varies around the world.
For example, in the United States, 1 in 1,500 people is considered rare, but in Japan, 1 in 2,500 people is considered rare.
Either way, it’s easier to recruit individuals with rare diseases into a study, rather than start with a group of healthy individuals and wait to see who develops a rare disease in the future.
For example, in the United States, you’d have to follow a group of 30,000 healthy individuals over time, to identify 20 people who develop a rare disease.
Case-control studies are also useful in situations that may be unethical to test using other approaches.
A case-control study is an observational method used to compare a group of individuals with a particular condition (the cases) to another, a similar group of people without that condition (the controls). The investigation begins after researchers have identified a group of people with the condition they wish to study. A second, comparable group who does not have the condition is then identified from medical records or other sources. Investigators then look back through both groups' records to identify possible causes or risk factors for the condition. Case-control studies can be conducted relatively quickly and cheaply since researchers don't have to follow participants over time as they would in a cohort study. Another advantage is that case-control studies can be used to study rare conditions that would be challenging in a cohort study.
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